{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:18:31Z","timestamp":1793193511890,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,9,26]],"date-time":"2021-09-26T00:00:00Z","timestamp":1632614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001774","name":"University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1106274"],"award-info":[{"award-number":["1106274"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine: 1) inter\u2010rater reliability of quantitative measurements of ultrasound\u2010detected synovitis, meniscal extrusion, and osteophytes; and 2) construct (convergent) validity via correlations and absolute agreements between ultrasound\u2010 and gold\u2010standard magnetic resonance imaging (MRI)\u2010outcomes in knee osteoarthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Dynamic ultrasound images for supra\u2010patellar synovitis, meniscal extrusion, and osteophytes were acquired and quantified by a physician operator, musculoskeletal ultrasonographer, and medical student independently. On the same day, 3T MRI images were acquired. Effusion\u2010synovitis, meniscal extrusion, and osteophytes were quantified on sagittal or coronal proton\u2010density\u2010weighted fat\u2010suppressed noncontrast TSE sequences, respectively. Intra\u2010class correlation coefficients (ICCs), Pearson's correlations (r), and Bland\u2013Altman plots were used to analyze inter\u2010rater reliability, and correlations, and agreements between the two imaging modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010nine participants [48 females (53.9%)] with mean (standard deviation) age of 61.5\u2009\u00b1\u20096.9\u2009years were included. The inter\u2010rater reliability was excellent for osteophytes (ICC range\u00a0=\u00a00.90\u20130.96), meniscal extrusion (ICC range\u00a0=\u00a00.90\u20130.93), and synovitis (ICC range\u00a0=\u00a00.86\u20130.88).<\/jats:p><jats:p>The correlations between ultrasound pathologies and their MRI counterparts were very strong (ICC range\u00a0=\u00a00.85\u20130.98) except for lateral meniscal extrusion [0.66 (95% CI, 0.52\u20130.76)]. Bland\u2013Altman plots showed 0.01, 0.05, 0.10, 0.53, and 0.60\u2009mm larger size in ultrasound medial tibial and medial femoral osteophytes, medial meniscal extrusions, synovitis, and lateral meniscal extrusions with 95% limits of agreements [\u00b10.39, \u00b10.44, \u00b10.85, \u00b10.70, and \u00b10.90 (SDs)] than MRI measures, respectively. The lines of equality were within 95% CI of the mean differences (bias) only for medial osteophytes and medial meniscal extrusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The quantitative assessment of synovitis, meniscal extrusion, and osteophytes generally showed excellent inter\u2010rater reliability and strong correlations with MRI\u2010based measurements. Absolute agreement was strong for medial tibiofemoral pathologies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15840","type":"journal-article","created":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T15:34:26Z","timestamp":1632756866000},"page":"1559-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Reliability and Convergent Construct Validity of Quantitative Ultrasound for Synovitis, Meniscal Extrusion, and Osteophyte in Knee Osteoarthritis With <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4065-7395","authenticated-orcid":false,"given":"Win Min","family":"Oo","sequence":"first","affiliation":[{"name":"Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute University of Sydney  Sydney NSW Australia"},{"name":"Department of Physical Medicine and Rehabilitation, Mandalay General Hospital 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