{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:37:37Z","timestamp":1771918657665,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T00:00:00Z","timestamp":1635465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe the sonographic findings of endometrial intraepithelial neoplasia (EIN), a precursor of endometrial cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases were found by word search of pathology database 1\/2013 to 6\/2019. One hundred and seventy\u2010eight patients with ultrasound &lt;1\u2009year prior to biopsy were included. Medical records were searched for patient data. Two radiologists blindly classified images. Differences of opinion were decided by clinical report. Univariate and multivariate analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median time between ultrasound and first sampling procedure was 49\u2009days. Median age was 55 (range 28\u201385) years. Endometrial thickness ranged from 2 to 90\u2009mm. Mean endometrial thickness was 13\u2009\u00b1\u20096\u2009mm in the noncancer group and 16\u2009\u00b1\u200911\u2009mm in the cancer group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). The endometrium was almost always heterogeneous 175\/178 (98%). Cysts were almost always multiple (89\/109, 82%) and &gt;1\u2009mm (72\/109, 66%). Masses were most often &gt;5\u2009mm (56\/105, 55%) and ill\u2010defined (41\/105, 39%). Vascularity was present in 93\/178 examinations (52%) and always associated with cysts and\/or mass. There were 92 cancers, 25 with invasion (including 4 with tumor extension into adenomyosis). In 47 cases, the endometrial\u2010myometrial interface was graded as ill\u2010defined, 39 of whom had hysterectomy. There was macroscopic cancer in 11, microscopic cancer in 4, and invasive carcinoma in 12 patients (<jats:italic>P<\/jats:italic> for invasive cancer versus other outcomes\u00a0=\u00a0.02). Depth of invasion was 5\u2010 &gt;95%, with 6 cancers &gt;50%. Multivariate analysis showed thickness, polyps, and type of bleeding as the best set of independent variables for cancer (area under the receiver operating characteristic (ROC) curve [AUC]\u00a0=\u00a0.75). Replacing type of bleeding with age or menopausal status had AUC of .73 and .74, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>EIN has a variety of sonographic appearances with thickened endometrium with cysts and masses being common. Ill\u2010definition of the endometrial\u2010myometrial interface is a poor prognostic finding when seen in the absence of adenomyosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15854","type":"journal-article","created":{"date-parts":[[2021,10,29]],"date-time":"2021-10-29T13:08:27Z","timestamp":1635512907000},"page":"1723-1737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Sonographic Appearance of Endometrial Intraepithelial Neoplasia"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7761-6493","authenticated-orcid":false,"given":"Deborah","family":"Levine","sequence":"first","affiliation":[{"name":"Department of Radiology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia C.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Radiology Associates of Florida  Tampa FL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlene","family":"Kwan","sequence":"additional","affiliation":[{"name":"University of California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Brook","sequence":"additional","affiliation":[{"name":"Department of Radiology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa M.","family":"Jorgensen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Kappler","sequence":"additional","affiliation":[{"name":"Washington Radiology Associates  Fairfax VA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan L.","family":"Hecht","sequence":"additional","affiliation":[{"name":"Department of Pathology Beth Israel Deaconess Medical Center, Harvard Medical School  Boston MA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,29]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"Key Statistics for Endometrial Cancer.https:\/\/www.cancer.org\/cancer\/endometrial-cancer\/about\/key-statistics.html. 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