{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:12:03Z","timestamp":1791720723347,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the impact of marginal (MCI) or velamentous (VCI) cord insertion on uterine artery pulsatility index (UtA PI), preeclampsia (PE), and offspring's birthweight (BW).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study of singleton pregnancies, undergoing routine anomaly scan at 20<jats:sup>+0<\/jats:sup>\u201323<jats:sup>+6<\/jats:sup> gestational weeks, was conducted between 2016 and 2020. The effect of placental cord insertion on BW and UtA mean PI <jats:italic>z<\/jats:italic>\u2010scores was assessed using the <jats:italic>t<\/jats:italic> test or analysis of variance and post\u2010hoc tests; their association with PE was evaluated with the chi\u2010square test. A multivariate logistic regression model was employed to assess the independent association of placental cord insertion and UtA PI <jats:italic>z<\/jats:italic>\u2010score with PE, BW &lt;10th, &lt;5th centile, and intrauterine death (IUD), using specific confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study population included 4453 pregnancies. Conception via assisted reproductive technology (ART) was associated with increased risk of abnormal cord insertion (odds ratio [OR]: 2.237; 95% confidence interval [CI]: 1.561\u20133.206; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Women with MCI\/VCI had higher mean UtA PI <jats:italic>z<\/jats:italic>\u2010score than those with central\/eccentric (0.29 vs 0.01; mean difference: \u22120.28; 95% CI: \u22120.399 to \u22120.165; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). MCI\/VCI were associated with higher rates of BW &lt;10th centile (central\/eccentric: 16.2% vs MCI: 21.9% vs VCI: 35.7%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) and BW &lt;5th centile (9.8 vs 15.1 vs 23.2%, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). No association was identified between MCI\/VCI and PE (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.968). Finally, VCI (aOR: 13.717; 95% CI: 1.576\u2013119.379; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.018) and increased BMI (aOR: 1.167; 95% CI: 1.071\u20131.271; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) significantly correlated with IUD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal cord insertion is more common in ART pregnancies. MCI\/VCI are associated with higher mean UtA PI and lower BW centile, but not with increased risk of PE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15883","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T10:35:33Z","timestamp":1637145333000},"page":"2011-2018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Impact of Marginal and Velamentous Cord Insertion on Uterine Artery Doppler Indices, Fetal Growth, and Preeclampsia"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4337-7871","authenticated-orcid":false,"given":"Ioannis","family":"Tsakiridis","sequence":"first","affiliation":[{"name":"Third Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki 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Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0876-5596","authenticated-orcid":false,"given":"Alexandros","family":"Sotiriadis","sequence":"additional","affiliation":[{"name":"Second Department of Obstetrics and Gynaecology, School of Medicine, Faculty of Health Sciences Aristotle University of Thessaloniki  Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Pathology of the Human Placenta","author":"Benirschke K","year":"2006"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-017-0641-1"},{"key":"e_1_2_6_4_1","volume-title":"Human Trophoblast","author":"Hertig 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