{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:30:08Z","timestamp":1793039408650,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004374","name":"Chongqing Medical University","doi-asserted-by":"publisher","award":["2018079"],"award-info":[{"award-number":["2018079"]}],"id":[{"id":"10.13039\/501100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the efficacy of low\u2010intensity focused ultrasound (LIFU) treatment on rapid relief of delayed\u2010onset muscle soreness (DOMS) triggered by high\u2010intensity exercise.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 16 healthy male college students were randomly divided into two groups: the LIFU group (<jats:italic>n<\/jats:italic>\u00a0=\u00a08) and the Sham group (<jats:italic>n<\/jats:italic>\u00a0=\u00a08). After the exercise protocol, the LIFU group received treatment, which parameters included that the power output was 2.5\u00a0W\/cm<jats:sup>2<\/jats:sup>, the frequency was 1\u00a0MHz, and the treating time was 20\u00a0minutes. The Sham group was treated with LIFU without energy output. Visual analog scale was used to evaluate the level of DOMS in every participant. The activities of plasma creatine kinase, lactate dehydrogenase, and the plasma concentration were measured by spectrophotometry. Tumor necrosis factor\u2010\u03b1 and interleukin\u20106 of serum were analyzed by enzyme\u2010linked immunosorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The visual analog scale of quadriceps femoris and\/or calf muscles in the LIFU group decreased significantly at 24\u2009hours (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and 48\u2009hours (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) after the exercise protocol. Both the accumulation of lactic acid (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) in muscle and the activity of lactate dehydrogenase (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01) reduced immediately after LIFU treatment. The activities of tumor necrosis factor\u2010\u03b1 and interleukin\u20106 24\u00a0hours lowered in the LIFU group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LIFU treatment could relieve muscle soreness rapidly and effectively in the early stages of DOMS. The application of LIFU may provide a potential strategy for clinical treatment for DOMS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15904","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T06:14:46Z","timestamp":1638598486000},"page":"2227-2235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Potential Application of Low\u2010Intensity Focused Ultrasound in Rapidly Relieving Delayed\u2010Onset Muscle Soreness Induced by High\u2010Intensity Exercise"],"prefix":"10.1002","volume":"41","author":[{"given":"Yi","family":"Xia","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Key Laboratory of Biomedical Engineering Chongqing Medical University  Chongqing 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