{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T11:10:42Z","timestamp":1750158642653,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the accuracy, sensitivity, and specificity of contrast\u2010enhanced ultrasound (CEUS) for detection of parathyroid adenomas and compare it to those of 4\u2010dimensional computed tomography (4DCT), which has been established as a reliable, effective tool for preoperative localization of parathyroid adenomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>About 27 patients with suspected parathyroid pathology underwent imaging evaluations with 4DCT and CEUS and 22 patients subsequently underwent surgical resection of parathyroid lesions. 4DCT and CEUS were performed and interpreted by consensus of two expert radiologists with extensive experience in each modality. Assessment for the side, z\u2010axis (craniocaudal axis), and quadrant of the pathologically proven lesion was performed based on the surgical report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For single\u2010gland disease, the accuracy for CEUS localization to the correct quadrant and side were 81.0 and 90.1% respectively. For single\u2010gland disease, the accuracy for 4DCT localization to the correct quadrant and side were 81.0 and 90.5% respectively. 4DCT localization sensitivity and specificity were comparable to those for CEUS. 4DCT allowed for accurate diagnosis in multigland disease in contradistinction to CEUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CEUS is a noninvasive, real\u2010time imaging technique that has relatively high diagnostic confidence and accuracy of localization which are comparable to the accuracy of 4DCT for preoperative parathyroid adenoma detection, characterization, and localization.<\/jats:p><jats:p>This technique should be considered for primary preoperative diagnosis, especially in younger patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15916","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T06:39:36Z","timestamp":1639723176000},"page":"2295-2306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Utility of Contrast\u2010Enhanced Ultrasound and 4\u2010Dimensional Computed Tomography for Preoperative Detection and Localization of Parathyroid Adenomas Compared With Surgical Results"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9214-7912","authenticated-orcid":false,"given":"Alexander","family":"Lerner","sequence":"first","affiliation":[{"name":"Department of Radiology USC Keck School of Medicine, University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward G.","family":"Grant","sequence":"additional","affiliation":[{"name":"Department of Radiology USC Keck School of Medicine, University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jay","family":"Acharya","sequence":"additional","affiliation":[{"name":"Department of Radiology USC Keck School of Medicine, University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamara N.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology USC Keck School of Medicine, University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis R.","family":"Maceri","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology USC Keck School of Medicine, University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven Yong","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Neurology USC Keck School of Medicine, University of Southern California  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisham","family":"Tchelepi","sequence":"additional","affiliation":[{"name":"Department of Radiology USC Keck School of Medicine, University of Southern California  Los Angeles CA 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