{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T23:07:40Z","timestamp":1787872060689,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Grant #146442 \u2010 Non\u2010communicable Diseases in Obste"],"award-info":[{"award-number":["Grant #146442 \u2010 Non\u2010communicable Diseases in Obste"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Cerebro\u2010placental ratio (CPR) is a doppler tool contributes to clinical decision\u2010making in pregnancies affected by small for gestational age weight (SGA). Pregnancies affected by gestational diabetes mellitus (GDM) tend to have higher newborn weight, but greater risk of adverse perinatal outcomes. We hypothesized that in GDM\u2010complicated\u2010pregnancies CPR will be associated with adverse perinatal outcomes even in the absence of SGA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective single\u2010center cohort study included non\u2010anomalous singleton pregnancies in women with GDM. Those with pre\u2010pregnancy diabetes mellitus, hypertensive disorder or suspected SGA were excluded. Routine fetal sonographic assessment included CPR\u2014defined as middle cerebral artery pulsatilty index\/umbilical artery pulsatilty index. Masked CPR measurement closest to birth was used, classified as &gt;10th (normal) or \u226410th centile (low). Primary outcome was a composite, consisting of stillbirth, Caesarean birth due to abnormal fetal heart rate pattern, 5\u2010minute Apgar &lt;7, cord arterial pH\u2009&lt;\u20097.0, hypoxic ischemic encephalopathy, or NICU admission &gt;24\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 281 participants, 24 (8.5%) had low CPR, at a mean gestational age of 36.3\u2009weeks (IQR 34.0\u201337.4). Birthweight percentile was significantly lower among the low CPR group (35th [IQR 16\u201331] versus 60th [IQR 31\u201382]; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002). There was no statistically difference in the primary composite outcome between the groups (8.3% versus 7.0%, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.68). Low CPR was significantly associated with a higher risk of neonatal hypoglycemia (adjusted odds ratio 3.2, 95% CI 1.2\u20138.3).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In pregnancies affected by GDM, CPR \u226410th percentile was not associated with adverse perinatal outcome but was associated with neonatal hypoglycemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15961","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T11:33:23Z","timestamp":1645097603000},"page":"2767-2774","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of the Cerebro\u2010Placental Ratio With Adverse Outcomes in Pregnancies Affected by Gestational Diabetes Mellitus"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4275-1780","authenticated-orcid":false,"given":"Yael","family":"Ganor Paz","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Samson Assuta Ashdod University Hospital, Ben Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5496-4866","authenticated-orcid":false,"given":"Eran","family":"Barzilay","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Samson Assuta Ashdod University Hospital, Ben Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraya","family":"Saied Idriss","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bnai\u2010Zion Medical Center, Faculty of Medicine Technion\u2010Israel Institute of Technology  Haifa Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth","family":"Murray\u2010Davis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Midwifery Education Program McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Melamed","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology Sunnybrook Health Sciences Centre, University of Toronto  Toronto, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Ray","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Obstetrics and Gynaecology St. Michael's Hospital, University of Toronto  Toronto, Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Geary","sequence":"additional","affiliation":[{"name":"Department of Obstetrics &amp; Gynaecology Rotunda Hospital  Dublin 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