{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T22:54:07Z","timestamp":1781650447905,"version":"3.54.5"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study examines fetuses with tetralogy of Fallot (TOF) and evaluates the right (RV) and left (LV) ventricular contractility and LV function using speckle\u2010tracking analysis of the endocardium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study group consisted of 44 fetuses with TOF, of which 34% had pulmonary valve atresia (<jats:italic>N<\/jats:italic>\u00a0=\u00a015) and 59% (<jats:italic>N<\/jats:italic>\u00a0=\u00a026) had pulmonary valve stenosis. The RV and LV global fractional area change, longitudinal contractility (longitudinal strain, free wall strain, septal strain, free wall and septal annular fractional shortening, and free wall and septal wall annular plane systolic excursion), and transverse contractility (24\u2010segment fractional shortening) as well as LV functional assessment (stroke volume, cardiac output, and ejection fraction) were measured using speckle\u2010tracking analysis. The <jats:italic>z<\/jats:italic>\u2010scores of the measurements were compared to 200 controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, measurements of LV contractility in fetuses with TOF demonstrated significantly abnormal values for global contractility, longitudinal contractility, and transverse contractility of the mid and apical segments. LV function was abnormal for stroke volume (SV), cardiac output (CO), and ejection fraction (EF). In comparison, RV contractility demonstrated no significant difference between TOF and control <jats:italic>z<\/jats:italic>\u2010score values for RV global contractility. Only two RV measurements were found to be abnormal: longitudinal contractility and transverse contractility of the apical segments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Using multiple measurement tools to evaluate global, longitudinal, and transverse contractility, this study identified significant differences between fetuses with TOF and healthy controls, with greater contractility abnormalities seen in the LV than in the RV.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.15987","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T14:58:54Z","timestamp":1649516334000},"page":"2955-2964","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Speckle\u2010Tracking Analysis in Fetuses With Tetralogy of Fallot: Evaluation of Right and Left Ventricular Contractility and Left Ventricular Function"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-572X","authenticated-orcid":false,"given":"Greggory R.","family":"DeVore","sequence":"first","affiliation":[{"name":"Fetal Diagnostic Centers  Pasadena California USA"},{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology David Geffen School of Medicine, UCLA  Los Angeles California USA"},{"name":"Department of Obstetrics and Gynecology Wayne State University  Detroit Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3807-7022","authenticated-orcid":false,"given":"Yalda","family":"Afshar","sequence":"additional","affiliation":[{"name":"Division of Maternal\u2010Fetal Medicine, Department of Obstetrics and Gynecology David Geffen School of Medicine, UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Harake","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics UCLA Mattel Children's Hospital, David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Satou","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics UCLA Mattel Children's Hospital, David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9146-0701","authenticated-orcid":false,"given":"Mark","family":"Sklansky","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Department of Pediatrics UCLA Mattel Children's Hospital, David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.187"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1992.11.7.345"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15639"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14454"},{"key":"e_1_2_6_6_1","article-title":"Twenty\u2010four segment transverse ventricular fractional shortening: a new technique to evaluate fetal cardiac function","author":"DeVore GR","year":"2017","journal-title":"J Ultrasound 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