{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:26:14Z","timestamp":1747171574812,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the thickness of levator palpebra superioris\u2010Muller's muscle complex (LMC) on ultrasound biomicroscopy (UBM) and to correlate with the clinical response to botulinum toxin A (BTA) injection in patients with inactive\u2010stage of thyroid\u2010related upper eyelid retraction (UER). We also studied the correlation of clinical parameters, preinjection with postinjection values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a prospective, interventional study. Patients with thyroid\u2010related UER who underwent subconjunctival injection of BTA were recruited. Demographic data and clinical details were evaluated. UBM (50\u2009MHz) was done to measure the thickness of LMC. Patient's satisfaction was graded at each follow\u2010up. Follow\u2010up was done at 1\u00a0week, 1\u2009month, and 3\u2009months' time intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 13 patients were recruited and 26 eyes were divided into two groups; group 1 included eyes with UER (<jats:italic>n<\/jats:italic>\u00a0=\u00a017), and group 2 included eyes without UER (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). There was a statistically significant reduction in margin reflex distance 1 (MRD1) after BTA injection at 1\u2010week, 1\u2010month, and 3\u2010months follow\u2010up with maximum reduction at 1\u2009month. The mean LMC thickness of 26 eyes was 0.96\u2009mm which was found to be significantly more than normal controls. On comparison of mean LMC thickness with the amount of UER and reduction in MRD1, we did not find a significant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with TED have significantly thicker LMC on UBM than controls. Further studies are needed with a larger sample size on the correlation of UBM features of levator aponeurosis with response to BTA injection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16004","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T10:46:39Z","timestamp":1652352399000},"page":"399-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Correlation of Levator\u2010Muller's Complex Thickness on <scp>Ultrasound Biomicroscopy<\/scp> to Botulinum Toxin A Injection in Thyroid\u2010Related Upper Eyelid Retraction"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-2608","authenticated-orcid":false,"given":"Sindhuja","family":"Kandasamy","sequence":"first","affiliation":[{"name":"Oculoplastics &amp; Oncology Services All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6667-249X","authenticated-orcid":false,"given":"Sahil","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Oculoplastics &amp; Oncology Services All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelam","family":"Pushker","sequence":"additional","affiliation":[{"name":"Oculoplastics &amp; Oncology Services All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachna","family":"Meel","sequence":"additional","affiliation":[{"name":"Oculoplastics &amp; Oncology Services All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandeep S.","family":"Bajaj","sequence":"additional","affiliation":[{"name":"Oculoplastics &amp; Oncology Services All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velpandian","family":"Thirumurthy","sequence":"additional","affiliation":[{"name":"Department of Ocular Pharmacology, Dr R. 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