{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:30:17Z","timestamp":1747150217738,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,5,27]],"date-time":"2023-05-27T00:00:00Z","timestamp":1685145600000},"content-version":"am","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["W911NF\u201016\u20102\u20100035"],"award-info":[{"award-number":["W911NF\u201016\u20102\u20100035"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Lung ultrasound (LUS) may help determine illness severity in children with acute lower respiratory tract infections (LRTI) but limited pediatric studies exist. Our objective was to determine the association between LUS findings and illness severity in children with LRTI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective study of patients &lt;20\u2009years with LRTI. Trained investigators performed standardized LUS examinations of 12 regions. Blinded sonologists reviewed examinations for individual pathologic features and also calculated a Quantified Lung Ultrasound Score (QLUS). We defined focal severity as QLUS of \u22652 in \u22651 region, and diffuse severity as QLUS of \u22651 in \u22653 regions. The primary outcome was the Respiratory component of the Pediatric Early Warning Score (RPEWS), a 14\u2010item scale measuring respiratory illness severity. Secondary outcomes included hospital admission, length of stay, supplemental oxygen, and antibiotic use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 85 patients with LRTIs, 46 (54%) whom were hospitalized (5.4% intensive care). Median RPEWS was 1 (interquartile range 2). Neither individual features on ultrasound nor total QLUS were associated with RPEWS, hospitalization, length of stay, or oxygen use. Mean RPEWS was similar for participants regardless of focal (1.46 versus 1.26, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.57) or diffuse (1.47 versus 1.21, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.47) severity findings, but those with focal or diffuse severity, or isolated consolidation, had greater antibiotic administration (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In children with LRTI, neither individual features nor QLUS were associated with illness severity. Antibiotics were more likely in patients with either focal or diffuse severity or presence of consolidation on ultrasound.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16023","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T07:18:24Z","timestamp":1653635904000},"page":"3013-3022","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lack of Association Between a Quantified Lung Ultrasound Score and Illness Severity in Pediatric Emergency Department Patients With Acute Lower Respiratory Infections"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1636-7320","authenticated-orcid":false,"given":"David","family":"Kessler","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Columbia University Vagelos College of Physicians and Surgeons New York Presbyterian Morgan Stanley Children's Hospital  New York New York 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USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Columbia University Vagelos College of Physicians and Surgeons New York Presbyterian Morgan Stanley Children's Hospital  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam M.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruthie","family":"Birger","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences Columbia University  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeff","family":"Shaman","sequence":"additional","affiliation":[{"name":"Mailman School of Public Health Columbia University  New York New York 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