{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T18:49:41Z","timestamp":1776710981581,"version":"3.51.2"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T00:00:00Z","timestamp":1655078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760314"],"award-info":[{"award-number":["81760314"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This is a prospective study to evaluate the clinical value of high\u2010frequency ultrasound (HFUS), superb microvascular imaging (SMI), and contrast\u2010enhanced ultrasound (CEUS) in differentiation of pigmented villonodular synovitis (PVNS) and highly active rheumatoid arthritis (RA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty PVNS patients and 24 active RA patients were selected to undergo HFUS, SMI, and CEUS examinations. The characteristics of HFUS, SMI, and CEUS in PVNS and RA were compared, and the differential diagnosis performances of HFUS, SMI, and CEUS in PVNS and RA were evaluated by receiver operating characteristic (ROC) analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were statistically significant in joint effusion, synovial thickness, synovial morphology, synovial echo, synovial vessel shape, synovial enhanced direction, and enhanced pattern between PVNS and RA (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). However, no statistically significant were found in bone erosion, synovial boundary, blood signal grading of synovium, synovial enhanced strength, and CEUS quantitative parameters (including PI, TTP, S, MTT, and AUC) (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05). The AUC of HFUS, SMI, and CEUS for differential diagnosis PVNS and RA were 0.832, 0.675, and 0.817, respectively. The AUC of HFUS\u2009+\u2009SMI, HFUS\u2009+\u2009CEUS, SMI\u2009+\u2009CEUS, HFUS\u2009+\u2009SMI\u2009+\u2009CEUS were 0.923, 0.940, 0.817, and 0.940, respectively. The AUC of HFUS\u2009+\u2009SMI and HFUS\u2009+\u2009CEUS was higher than that of each alone (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HFUS, SMI, and CEUS can be used as supplementary methods for diagnosis and differential diagnosis in PVNS and active RA. What is more, the combination of HFUS\u2009+\u2009SMI and HFUS\u2009+\u2009CEUS was suggested.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16040","type":"journal-article","created":{"date-parts":[[2022,6,13]],"date-time":"2022-06-13T09:09:17Z","timestamp":1655111357000},"page":"585-593","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Contribution of the Ultrasound Techniques in the Evaluation of Knee Joint Damage in the Case of <scp>Pigmented Villonodular Synovitis<\/scp> and <scp>Rheumatoid Arthritis<\/scp>"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9424-744X","authenticated-orcid":false,"given":"Yan\u2010Fen","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasonics The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui\u2010Hong","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Xian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan\u2010Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi\u2010Gui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasonics The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,13]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"731","article-title":"Pigmented villonodular synovitis, bursitis, and tenosynovitis","volume":"31","author":"Jaffe HL","year":"1941","journal-title":"Arch Pathol"},{"key":"e_1_2_6_3_1","first-page":"35","article-title":"Clinical and ultrasonic diagnostic value of pigmented villonodular synovitis and active rheumatoid arthritis","volume":"12","author":"Zhang LY","year":"2015","journal-title":"Chin J Med Ultrasound"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1048923"},{"key":"e_1_2_6_5_1","first-page":"67","article-title":"Milwaukee shoulder syndrome associated with pigmented villonodular synovitis. 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