{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:30:37Z","timestamp":1747150237151,"version":"3.40.5"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to investigate real\u2010time elastography (RTE) use in the evaluation of the optic nerve head (ONH) and peripapillary structures for the diagnosis of primary open angle (POAG) and pseudoexfoliation (PEX) glaucoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013controlled study included 30 patients with POAG, 30 patients with PEX glaucoma, and 30 age\u2010matched control subjects. All of the participants underwent comprehensive ophthalmological examinations covering vessel density of optic nerve and retinal nerve fiber layer (RNFL) thickness measurements with optical cohorence tomography angiography and mean deviation (MD) measurements with Humphrey II Perimetry Visual Field Analyzer. In vivo evaluation of the biomechanical properties of the ONH and peripapillary structures were performed with RTE in all participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed higher ratios of orbital fat to optic nerve head (ROFON) values (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.008) and strain ratios of orbital fat to scleral\u2013choroidal\u2013retinal complex (ROFSCR) values (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) in the POAG group compared with PEX glaucoma group and higher ROFON (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.012) and ROFSCR values (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.004) in PEX glaucoma group than the control group. ROFON and ROFSCR values were positively correlated with glaucoma duration and negatively correlated with MD, radial peripapillary vessel density (RPCVD), and inside disc vessel density in both glaucoma groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.005; only in the PEX glaucoma group for MD and ROFSCR, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.445).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Determining the biomechanical properties of ONH and peripapillary structures with RTE in glaucomatous eyes may offer a new perspective on the diagnosis and follow\u2010up of the progression of the disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16157","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T17:25:06Z","timestamp":1671470706000},"page":"1471-1480","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Usability of Real\u2010Time Elastography for 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