{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:06:51Z","timestamp":1768824411175,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>In this study, we used the recently developed ultrasound elastography techniques sound touch elastography (STE) and sound touch quantification (STQ) to quantify portal hypertension (PHT) severity in a rat model of carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2010induced cirrhotic PHT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 60 rats were used. Various degrees of PHT were established. Liver and spleen stiffness were measured by STE (L\u2010STE and S\u2010STE, respectively) and STQ (L\u2010STQ and S\u2010STQ, respectively). We measured portal pressure (PP) after ultrasonographic examination. The performance of the STE and STQ parameters in the identification of PHT was evaluated using receiver operating characteristic (ROC) analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Liver and spleen stiffness measurements obtained with STE and STQ correlated positively with the PP (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.566\u20130.882, all <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The areas under ROC curves for L\u2010STE, S\u2010STE, L\u2010STQ, and S\u2010STQ values were 0.931 (95% confidence interval [CI], 0.847\u20131.000), 0.982 (95% CI, 0.956\u20131.000), 0.796 (95% CI, 0.680\u20130.912), and 0.925 (95% CI, 0.858\u20130.993), respectively, for PP \u22655\u2009mmHg; 0.937 (95% CI, 0.865\u20131.000), 0.938 (95% CI, 0.864\u20131.000), 0.967 (95% CI, 0.923\u20131.000), and 0.960 (95% CI, 0.897\u20131.000), respectively, for PP \u226510\u2009mmHg; and 0.954 (95% CI, 0.897\u20131.000), 0.790 (95% CI, 0.652\u20130.928), 0.808 (95% CI, 0.680\u20130.935), and 0.740 (95% CI, 0.595\u20130.885), respectively, for PP \u226512\u2009mmHg.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>STE and STQ are reliable noninvasive tools for the assessment of PHT severity, especially for PP \u226510\u2009mmHg, in a rat model of CCl<jats:sub>4<\/jats:sub>\u2010induced cirrhotic PHT.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16172","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T17:15:51Z","timestamp":1673630151000},"page":"1537-1547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Use of Sound Touch Elastography and Sound Touch Quantification for the Noninvasive Evaluation of Portal Hypertension in a Rat Model"],"prefix":"10.1002","volume":"42","author":[{"given":"Bingtian","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Fujian Medical University  Quanzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5109-5474","authenticated-orcid":false,"given":"Guorong","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Fujian Medical University  Quanzhou 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