{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T20:52:02Z","timestamp":1779396722431,"version":"3.53.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T00:00:00Z","timestamp":1673568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To analyze the risk factors of sulfur hexafluoride microbubble contrast agent intravasation during hysterosalpingo\u2010contrast sonography (HyCoSy), and to explore a simple prediction model by the obvious clinical history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective study included 299 infertility women who had undergone HyCoSy examination from July 1, 2018 to June 31, 2019. The factors were recorded, including age, endometrial thickness, balloon length, infertility type, history of intrauterine surgery, history of pelvic surgery, and tubal patency. The method of multivariate logistic regression analysis was adopted to analyze the risk factors affecting the contrast agent intravasation, and the receiver operating characteristic curves were plotted to test their efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Secondary infertility, a history of intrauterine surgery, thin endometrial thickness, and tubal obstruction were all risk factors of the occurrence of intravasation (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). And the area under the receiver operating characteristic curves of the multifactor\u2010combined prediction model of the intravasation was significantly larger than that of single\u2010factor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sonographers and gynecologists should be familiar with the risk factors of intravasation and select the appropriate timing of HyCoSy toward reducing the occurrence of intravasation and other complications after thoroughly explaining and communicating with the patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16179","type":"journal-article","created":{"date-parts":[[2023,1,13]],"date-time":"2023-01-13T17:22:36Z","timestamp":1673630556000},"page":"1587-1594","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Risk Factors of Contrast Agent Intravasation With Sulfur Hexafluoride Microbubble During Hysterosalpingo\u2010Contrast Sonography"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0611-8256","authenticated-orcid":false,"given":"Bin\u2010Bin","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Ling","family":"Teng","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0167-3173","authenticated-orcid":false,"given":"Shang\u2010Yong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning 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