{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:21:50Z","timestamp":1781259710080,"version":"3.54.1"},"reference-count":18,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T00:00:00Z","timestamp":1675641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23DK119949"],"award-info":[{"award-number":["K23DK119949"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Examine whether repeat nasal bone evaluation following an absent\/uncertain nasal bone on first\u2010trimester screening (FTS) improves Down syndrome (DS) screening specificity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review of FTS sonograms in one center from January 2015 to January 2018 was performed. Data was extracted for those with an absent\/uncertain nasal bone. Repeat evaluations were offered.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 6780 FTS sonograms, 589 (8.7%) had an absent\/uncertain nasal bone. Upon repeat exam, 268\/376 (71.3%) had a present nasal bone. Compared with Black patients, patients of other ethnicities were more likely to have a present nasal bone on exam 2 (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.00001). Of 268 patients with a present nasal bone on exam 2, 37 (13.8%) had an abnormal DS risk following exam 1; 34\/37 (91.9%) normalized following nasal bone visualization, dropping the screen positive rate to 1.1%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Repeat nasal bone examination is beneficial in refining DS risk assessment and improves the specificity of FTS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16190","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T10:49:32Z","timestamp":1675680572000},"page":"1709-1716","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Follow Your Nose"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8567-3850","authenticated-orcid":false,"given":"Kristen A.","family":"Miller","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelynn G.","family":"Sagaser","sequence":"additional","affiliation":[{"name":"Juno Diagnostics  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine B.","family":"Hertenstein","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin J.","family":"Blakemore","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine R.","family":"Forster","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Sibley Memorial Hospital, Johns Hopkins Medicine  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathleen S.","family":"Lawson","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angie C.","family":"Jelin","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Gynecology and Obstetrics Johns Hopkins Hospital  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,6]]},"reference":[{"key":"e_1_2_6_2_1","article-title":"Screening for fetal aneuploidy. 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