{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:30:02Z","timestamp":1773808202269,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:00:00Z","timestamp":1685750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960329"],"award-info":[{"award-number":["81960329"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160350"],"award-info":[{"award-number":["82160350"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160336"],"award-info":[{"award-number":["82160336"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The present study aimed to determine the feasibility of the American College of Radiology's (ACR) contrast\u2010enhanced ultrasound (CEUS) Liver Imaging Reporting and Data System (LI\u2010RADS) (version 2017) in examinations using Sonazoid and compare its diagnostic performance with that of modified LI\u2010RADS in patients at high risk of hepatocellular carcinoma (HCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study's sample population consisted of 137 participants with a total of 140 nodules who underwent CEUS with Sonazoid and pathological confirmation via surgery or biopsy from January 2020 to February 2022. The lesions were evaluated and classified based on the reference standards (ie, ACR CEUS LI\u2010RADS and modified LI\u2010RADS). The overall diagnostic capabilities of the two systems were evaluated in terms of accuracy, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) with 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The participants had a median age of 51\u2009years and an interquartile range of 43\u201358\u2009years. Regarding LR\u20105 as a predictor of HCC, the accuracy results of the ACR LI\u2010RADS and modified LI\u2010RADS algorithms were 72.9 and 71.4%, respectively (<jats:italic>P<\/jats:italic>\u2009=\u2009.50). The sensitivity of both systems was the same (69.7%; 95% CI: 60.7\u201377.8%). Regarding LR\u2010M as a predictor of non\u2010HCC malignancy, the diagnostic performance of the algorithms was the same, with accuracy and sensitivity results of 76.4 and 73.3%, respectively (95% CI: 44.9\u201392.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings indicate that modified LI\u2010RADS had a moderate level of diagnostic performance for HCC in examinations using Sonazoid, which was comparable to ACR LI\u2010RADS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16282","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T11:15:16Z","timestamp":1685790916000},"page":"2501-2511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of the Feasibility and Diagnostic Performance of <scp>ACR CEUS LI\u2010RADS<\/scp> and a Modified <scp>CEUS LI\u2010RADS<\/scp> for <scp>HCC<\/scp> in Examinations Using Sonazoid"],"prefix":"10.1002","volume":"42","author":[{"given":"Wei","family":"Liao","sequence":"first","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiao","family":"Que","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medical Ultrasound The First Affiliated Hospital of Guangxi Medical University  Nanning 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