{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:28:37Z","timestamp":1747150117517,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T00:00:00Z","timestamp":1689292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The present study assessed the diagnostic and prognostic significance of endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) for suspected intrathoracic metastasis after HNC treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on 75 patients with a prior history of head and neck cancer treatment who underwent EBUS\u2010TBNA for suspected intrathoracic metastases between March 2012 and December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 126 targeted lesions, including 107 mediastinal\/hilar lymph nodes and 19 intrapulmonary\/mediastinal masses, were sampled. The metastatic head and neck cancer (HNC) cases detected by EBUS\u2010TBNA consisted of nasopharyngeal carcinoma (n\u2009=\u200924), oropharyngeal carcinoma (n\u2009=\u20093), hypopharynx carcinoma (n\u2009=\u20096), laryngeal carcinoma (n\u2009=\u20096), and oral cavity carcinoma (n\u2009=\u20096). Cases with negative EBUS\u2010TBNA results consisted of tuberculosis (n\u2009=\u20099), sarcoidosis (n\u2009=\u20093), anthracosis (n\u2009=\u20099), and reactive lymphadenitis (n\u2009=\u20099). Six false\u2010negative cases were found among the 75 patients with suspected intrathoracic metastases. The diagnostic sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic accuracy of the EBUS\u2010TBNA procedure for metastatic HNC were 88.2, 100.0, 100.0, 80, and 92.0%, respectively. The diagnosis of HNC intrathoracic metastasis by EBUS\u2010TBNA correlated with an adverse prognosis in terms of overall survival (OS) (<jats:italic>P<\/jats:italic>\u2009=\u2009.008). The log\u2010rank univariate analysis and Cox regression multivariate analysis results indicated that the detection of metastatic HNC through EBUS\u2010TBNA was a significant independent prognostic factor for patients with HNC who had received prior treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Endobronchial ultrasound\u2010guided transbronchial needle aspiration is a safe, effective, and minimally invasive procedure for assessing suspected intrathoracic metastasis in HNC patients after treatment. The intrathoracic metastasis detected by EBUS\u2010TBNA has crucial prognostic significance in previously treated HNC patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16302","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T11:17:33Z","timestamp":1689333453000},"page":"2661-2672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Diagnostic and Prognostic Value of <scp>EBUS\u2010TBNA<\/scp> for Intrathoracic Metastasis in Previously Treated Patients With Head and Neck Cancer"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8790-0930","authenticated-orcid":false,"given":"Sheng\u2010Ping","family":"Li","sequence":"first","affiliation":[{"name":"Department of Endoscopy Center Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital &amp; Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic 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