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However, the diagnosis in the first trimester is elusive due to the small size of the facial structures and technical limitations present at this early gestational age. In this Commentary, we suggest the routine systematic ultrasound identification of easy\u2010to\u2010obtain landmarks to improve the detection of cleft lip and cleft palate in the first trimester. These include, but are not limited to, visualization of the primary palate using the coronal plane of the face looking for disruption at the base of the retronasal triangle, and visualization of the palate using the sagittal plane looking for the maxillary gap and loss of the superimposed line. Early prenatal detection of orofacial clefts would allow a more detailed search for associated chromosomal anomalies or genetic syndromes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16310","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T11:34:03Z","timestamp":1691494443000},"page":"2905-2909","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cleft Lip and Cleft Palate"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-7486","authenticated-orcid":false,"given":"Gabriele","family":"Tonni","sequence":"first","affiliation":[{"name":"Prenatal Diagnostic Centre, Department of Obstetrics and Neonatology Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), AUSL Reggio Emilia  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-574X","authenticated-orcid":false,"given":"Waldo","family":"Sepulveda","sequence":"additional","affiliation":[{"name":"FETALMED\u2013Maternal\u2010Fetal Diagnostic Center, Fetal Imaging Unit  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,8]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/09-217"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2018.05.016"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-32516-3_3"},{"key":"e_1_2_3_5_1","first-page":"145","volume-title":"First Trimester Ultrasound Diagnosis of Fetal Abnormalities","author":"Abuhamad A","year":"2017"},{"key":"e_1_2_3_6_1","first-page":"E1","article-title":"AIUM practice parameter for the performance of detailed diagnostic obstetric ultrasound examinations between 12\u2009weeks 0\u2009days and 13\u2009weeks 6\u2009days","volume":"40","year":"2021","journal-title":"J Ultrasound Med"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2022-0125"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26106"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7650"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-32516-3_1"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.7484"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.20238"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6430"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.6451"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.10139"},{"key":"e_1_2_3_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000350181"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15675"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21931"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.05084"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369797"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000496842"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20844"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.1515\/crpm-2011-0002"},{"key":"e_1_2_3_25_1","doi-asserted-by":"publisher","DOI":"10.12891\/ceog3406.2017"},{"key":"e_1_2_3_26_1","doi-asserted-by":"publisher","DOI":"10.1159\/000481773"},{"key":"e_1_2_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5257"},{"key":"e_1_2_3_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.22123"},{"key":"e_1_2_3_29_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573405618666220713103500"},{"key":"e_1_2_3_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23507"},{"key":"e_1_2_3_31_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.9.1443"},{"key":"e_1_2_3_32_1","unstructured":"The First\u2010Trimester Scan.www.fetalmedicine.com. 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