{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:56:22Z","timestamp":1792760182853,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:p>Ultrasound contrast agent (UCA) use is increasing. Recent isolated reports observed a rise in pain\u2010related adverse events with the intravenous administration of the UCA Definity in adults with sickle cell disease. To date, no studies have investigated the incidence of similar adverse events with UCA Lumason or Optison. We describe our experience regarding the safety of Lumason and Optison in children with sickle cell disease and trait who underwent contrast\u2010enhanced ultrasound exams in our department with intravenous, intravesical, and other intracavitary routes. No pain\u2010related or other adverse events were observed in this pediatric population with any route of UCA administration.<\/jats:p>","DOI":"10.1002\/jum.16341","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T10:25:27Z","timestamp":1699266327000},"page":"189-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety of Ultrasound Contrast Agents in Pediatric Patients With Sickle Cell Disease and Trait"],"prefix":"10.1002","volume":"43","author":[{"given":"Aikaterini","family":"Ntoulia","sequence":"first","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kassa","family":"Darge","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis A.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"},{"name":"Department of Pediatrics, Division of Hematology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan J.","family":"Back","sequence":"additional","affiliation":[{"name":"Department of Radiology Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"},{"name":"Perelman School of Medicine at the University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30193-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.418"},{"key":"e_1_2_6_4_1","volume-title":"GeneReviews((R))","author":"Bender MA","year":"1993"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510865"},{"key":"e_1_2_6_6_1","unstructured":"Centers for Disease Control and Prevention (CDC).Data & Statistics on Sickle Cell Disease."},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61029-X"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199709113371107"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/15353702211005392"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2022.100983"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-019-02412-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-021-02096-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-013-2746-6"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2006.05.031"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-021-05223-4"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2008.07.019"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218783"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjcr\/ytaa555"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2022.09.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14918"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.4250\/jcvi.2019.27.e31"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2019-230579"},{"key":"e_1_2_6_23_1","first-page":"420","article-title":"Study of haemoglobin S percentage and haematological parameters in sickle cell trait","volume":"46","author":"Pathak K","year":"2003","journal-title":"Indian J Pathol Microbiol"},{"key":"e_1_2_6_24_1","first-page":"113","article-title":"Hematological findings in 375 Sicilians with Hb S trait","volume":"75","author":"Schiliro G","year":"1990","journal-title":"Haematologica"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.26719\/2000.6.2-3.233"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-016-0786-8"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90458-8"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.17.2023"},{"key":"e_1_2_6_29_1","unstructured":"Definity. 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