{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T01:00:43Z","timestamp":1788397243405,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the value of percutaneous contrast\u2010enhanced ultrasound (PCEUS) in the identification and characterization of sentinel lymph node (SLN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 102 breast cancer patients were collected and underwent preoperative PCEUS, which was used to identify SLN and lymphatic drainage. SLNs were classified into 4 enhancement patterns, including 6 subtypes: homogeneous (I), featured inhomogeneous (II) including inhomogeneous hypoenhancement (IIa) and annular or semi\u2010annular enhancement (IIb), focal filling defect (III) including filling defect area\u2009&lt;\u200950% (IIIa) and filling defect area\u2009\u2265\u200950% (IIIb), and no enhancement (IV). The enhancement patterns of SLNs were compared with the final pathological diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The identification rate of SLNs using PCEUS was 100% (102\/102); the rate of identification of LCs was 100% (102\/102), and the coincidence rate was 98.0% (100\/102). Four lymphatic drainage patterns (LDPs) including 5 subtypes were found: single LC\/single SLN(74.5%), multiple LCs\/ single SLN (13.7%) including 2 subtypes:2 LCs\/1 SLN and 3 LCs\/1 SLN, single LC\/multiple SLNs (7.8%), and multiple LCs\/multiple SLNs (3.9%). A total of 86.3% (44\/51) of patients without axillary metastasis could be safely selected for types I, IIa, and IIb, while the axillary metastasis rates of types III and IV were 74.4%\u00a0and 87.5%, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Compared with grayscale US, the PCEUS significant improvement in diagnosing metastatic SLNs (.794 versus .579, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). For the SLN metastatic burden, Types I, IIa, IIb, and IIIa had \u22642 SLNs metastases, with a pathological coincidence rate of (64\/67, 95.5%), and types IIIb and IV had &gt;2 SLNs metastases, with a pathological coincidence rate of (25\/35, 71.4%) (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The AUC of PCEUS for the diagnosis of SLN metastatic status and burden was .794 and .879, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCEUS has a high identification rate for SLN and has good potential for diagnosing SLN metastatic status and burden by enhancement patterns.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16359","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T05:27:25Z","timestamp":1698211645000},"page":"293-303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Value of Percutaneous Contrast\u2010Enhanced Ultrasound in Sentinel Lymph Node Identification, Metastatic Status and Burden Diagnosis in Early Breast Cancer"],"prefix":"10.1002","volume":"43","author":[{"given":"Wenjing","family":"Pang","sequence":"first","affiliation":[{"name":"Ultrasound Medical Center Lanzhou University Second Hospital  Lanzhou China"},{"name":"Gansu Province Clinical Research Center for Ultrasonography  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Lanzhou University Second Hospital  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Zhu","sequence":"additional","affiliation":[{"name":"Ultrasound Medical Center Lanzhou University Second Hospital  Lanzhou China"},{"name":"Gansu Province Clinical Research Center for Ultrasonography  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Jia","sequence":"additional","affiliation":[{"name":"Ultrasound Medical Center Lanzhou University Second Hospital  Lanzhou China"},{"name":"Gansu Province Clinical Research Center for Ultrasonography  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9725-1743","authenticated-orcid":false,"given":"Fang","family":"Nie","sequence":"additional","affiliation":[{"name":"Ultrasound Medical Center Lanzhou University Second Hospital  Lanzhou China"},{"name":"Gansu Province Clinical Research Center for Ultrasonography  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21708"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2020.7597"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282-020-01120-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.0023"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199509000-00016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.05.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suronc.2020.06.005"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200105000-00012"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-012-0247-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181f08f32"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2022.02.014"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000491703"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0427"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957-020-01890-z"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5089-0"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-22-234"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-09139-x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2011.11.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09551-y"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11112104"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12565-018-0441-2"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15957"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2019.04.006"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs-22-10"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.12.019"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2021.02.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-4200"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00004.2008"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6633-0"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.16359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T06:37:26Z","timestamp":1705819046000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.16359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/jum.16359"],"URL":"https:\/\/doi.org\/10.1002\/jum.16359","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]},"assertion":[{"value":"2023-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}