{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:49:49Z","timestamp":1767034189048,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171938","82202156"],"award-info":[{"award-number":["82171938","82202156"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate corpus callosum (CC) size in fetuses with malformations of cortical development (MCD) and to explore the diagnostic value of three CC length (CCL) ratios in identifying cortical abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010center retrospective study in singleton fetuses at 20\u201337\u2009weeks of gestation between April 2017 and August 2022. The midsagittal plane of the fetal brain was obtained and evaluated for the following variables: length, height, area of the corpus callosum, and relevant markers, including the ratios of corpus callosum length to internal cranial occipitofrontal dimension (CCL\/ICOFD), corpus callosum length to femur length (CCL\/FL), and corpus callosum length to cerebellar vermian diameter (CCL\/VD).<\/jats:p><jats:p>Intra\u2010class correlation coefficient (ICC) was used to evaluate measurement consistency. The accuracy of biometric measurements in prediction of MCD was assessed using the area under the receiver\u2010operating\u2010characteristics curves (AUC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fetuses with MCD had a significantly decreased CCL, height (genu and splenium), and area as compared with those of normal fetuses (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), but there was no significant difference in body height (<jats:italic>P<\/jats:italic>\u2009=\u2009.326).<\/jats:p><jats:p>The CCL\/ICOFD, CCL\/FL, and CCL\/VD ratios were significantly decreased in fetuses with MCD when compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). The CCL\/ICOFD ratio offered the highest predictive accuracy for MCD, yielding an AUC of 0.856 (95% CI: 0.774\u20130.938, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), followed by CCL\/FL ratio (AUC, 0.780 (95% CI: 0.657\u20130.904), <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), CCL\/VD ratio (AUC, 0.677 (95% CI: 0.559\u20130.795), <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The corpus callosum biometric parameters in fetuses with MCD are reduced. The CCL\/ICOFD ratio derived from sonographic measurements is considered a promising tool for the prenatal detection of cortical malformations. External validation of these findings and prospective studies are warranted.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16451","type":"journal-article","created":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T13:28:49Z","timestamp":1711978129000},"page":"1265-1277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disproportion of Corpus Callosum in Fetuses With Malformations of Cortical Development"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-2748","authenticated-orcid":false,"given":"Yu\u2010Ting","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ultrasonic Medicine The First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jing","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine The First Affiliated 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