{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:55:16Z","timestamp":1793796916247,"version":"4.6.1"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T00:00:00Z","timestamp":1710720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cystic echinococcosis (CE), a helminth\u2010associated zoonosis caused by <jats:italic>Echinococcus granulosus<\/jats:italic>, poses a significant public health problem, particularly in pastoral\u2010rearing regions. The lack of uniform guidelines led to variations in CE management. Based on ultrasound data, the World Health Organization Informal Working Group on Echinococcosis (WHO\u2010IWGE) classification system categorizes cysts into active, transitional, and inactive groups.<\/jats:p><jats:p>This study assesses whether the therapeutic approach from liver human operation cases in North Khorasan province aligns with the WHO\u2010IWGE reference based on ultrasound data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The research is based on ultrasound data from liver CE human operation cases collected between 2018 and 2022. This retrospective study investigates the therapeutic protocol for (CE) in North Khorasan Province, Iran, comparing it with the WHO\u2010IWGE guidelines. We collect data from previously registered patients' medical information from our studied area's main CE surgical hospital. Moreover, as the first hospitalized survey in Iran, this study reveals insights into patient demographics, cyst stage prevalence, and treatment modalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Notably, more than half of the patients were treated for CE1 stage cysts, and CE4 cases, which generally do not require surgery, underwent open surgery. The results suggest a need for adherence to the \u201cwatch\u2010and\u2010wait\u201d approach in specific cases. All patients underwent successful surgeries, but we do not have access to follow\u2010up data from patients after discharge.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This descriptive study contributes to understanding the implementation of WHO guidelines in a regional context, shedding light on the challenges and variations in CE management. It seems, retraining courses for surgeons are required to update their knowledge of standard CE diagnostic and treatment methods.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16452","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T13:24:11Z","timestamp":1710768251000},"page":"1279-1287","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Discordance Therapeutic Protocol of Cystic Echinococcosis With <scp>WHO<\/scp> Guideline"],"prefix":"10.1002","volume":"43","author":[{"given":"Reza","family":"Shafiei","sequence":"first","affiliation":[{"name":"Vector\u2010Borne Diseases Research Center North Khorasan University of Medical Sciences  Bojnurd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina Sadat","family":"Mohajerzadeh","sequence":"additional","affiliation":[{"name":"Department of Radiology and Medical Physics School of Medicine, North Khorasan University 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Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-7271","authenticated-orcid":false,"given":"Nima","family":"Firouzeh","sequence":"additional","affiliation":[{"name":"Vector\u2010Borne Diseases Research Center North Khorasan University of Medical Sciences  Bojnurd 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