{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:11:28Z","timestamp":1792620688903,"version":"4.5.0"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JM\u2010569"],"award-info":[{"award-number":["2022JM\u2010569"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate changes in dynamic cerebral autoregulation (CA) during short\u2010term and long\u2010term exposure to high altitude with ultrasonography, and also study the sex differences in the response of CA to altitude.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the differences in dynamic CA and measured with Doppler ultrasound of the bilateral internal carotid artery (ICA), vertebral artery (VA), and middle cerebral artery (MCA) and the values of basic information within 48\u2009hours and at 2\u2009years after arrival at Tibet in 65 healthy Han young Chinese volunteers, meanwhile, we compared the resistance index (RI) and pulsatility index (PI) of the right MCA at inhale oxygen 8\u2009minutes when a newcomer with 2\u2009years after arrival at Tibet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With 2\u2009years of altitude exposure, the SaO<jats:sub>2<\/jats:sub> of all subjects was above 90%, the mean PEF, DAP, and HR values decreased, HGB increased compared within 48\u2009hours in same\u2010gender groups. Comparisons of cerebral hemodynamics between before 2\u2009years and after 2\u2009years within male and female groups, the mean RI and PI values of bilateral MCA after 2\u2009years were significantly higher than before 2\u2009years, at the same time, the mean RI and PI values of bilateral ICA were significant differences (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05) between male groups, with regard to female groups, showed that the mean RI and PI values of bilateral VA were significant differences (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Comparisons of Right MCA hemodynamics between after oxygen uptake 8\u2009minutes and 2\u2009years, the mean RI and PI values were no significant difference within male and female groups (<jats:italic>P<\/jats:italic>\u2009&gt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Acute mountain sickness could result from an alteration of dynamic autoregulation of cerebral blood flow, but the impaired autoregulation may be corrected with the extension of time, furthermore, the response of CA to altitude in males and females are different.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16467","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T11:08:29Z","timestamp":1714734509000},"page":"1441-1448","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Dynamic Cerebral Autoregulation During Long\u2010Term Exposure to High Altitude in Normal Subjects by Ultrasonography"],"prefix":"10.1002","volume":"43","author":[{"given":"Yuan","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Ultrasonic Medicine, Tangdu Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi Zhao","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Basic Medicine and Xijing Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine, Tangdu Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Kui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine, Tangdu Hospital Air Force Medical University  Xi'an 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altitude illness and related diseases\u2014a review","volume":"105","author":"Gudbjartsson T","year":"2019","journal-title":"Laeknabladid"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282327"}],"container-title":["Journal of Ultrasound in 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