{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:29:04Z","timestamp":1747150144780,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:00:00Z","timestamp":1715817600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007180","name":"Children's Hospital Colorado","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Mercapto acetyl tri\u2010glycine renogram (MAG3) scan has been the gold standard assessment of pediatric ureteropelvic junction obstruction (UPJO) but requires intravenous access and radiation exposure. While Doppler ultrasound measurements of resistive indices (RI) of the arcuate arteries have been proposed as an alternative assessment of obstruction, they have not been widely adopted in the pediatric population. We hypothesized that RI of the main renal artery (RA) is more strongly correlated with MAG3 findings than arcuate RI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Pediatric patients with unilateral Society for Fetal Urology grade 3\u20134 hydronephrosis undergoing concomitant RUS and MAG3 were recruited. Doppler ultrasound peak systolic velocity (PSV); RI of bilateral RA at the origin, middle, and hilum; and RI of the superior, middle, and lower pole arcuate arteries were obtained. MAG3 differential renal function (DRF) and <jats:italic>T<\/jats:italic>\u00bd were recorded. Differences in RI measurements (DRI) between the affected and normal kidney were calculated and compared with DRF and <jats:italic>T<\/jats:italic>\u00bd.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>31 patients (median 4.6\u2010month\u2010old) were enrolled. Only RA RI at the origin differed between affected and normal kidneys (<jats:italic>p<\/jats:italic> &lt; .001). DRI RA at the origin showed weak evidence for an association with MAG3 DRF &lt; 40% (<jats:italic>p<\/jats:italic> .07). DRI was not associated with <jats:italic>T<\/jats:italic>\u00bd &gt; 20 minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was weak evidence for an association between RA DRI at the origin and DRF but not with <jats:italic>T<\/jats:italic>\u00bd. These findings suggest that RA DRI may provide additional data in the evaluation of patients with UPJO to tailor the use of MAG3 and associated risk of radiation exposure to those patients most at risk for concomitant renal function impairment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16479","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T09:11:02Z","timestamp":1715850662000},"page":"1595-1604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Doppler Ultrasound and Resistive Indices in the Diagnosis of Ureteropelvic Junction Obstruction in the Pediatric Population"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9817-2246","authenticated-orcid":false,"given":"Mariana L.","family":"Meyers","sequence":"first","affiliation":[{"name":"Pediatric Radiology Department Children's Hospital Colorado  Aurora Colorado USA"},{"name":"Children's Hospital Colorado  Aurora Colorado USA"},{"name":"University of Colorado School of Medicine  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Walker","sequence":"additional","affiliation":[{"name":"Children's Hospital Colorado  Aurora Colorado USA"},{"name":"University of Colorado School of Medicine  Aurora Colorado USA"},{"name":"Department of Surgery, Division of Pediatric Urology Children's Hospital Colorado  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carter","family":"Sevick","sequence":"additional","affiliation":[{"name":"Adult and Child Center for Health Outcomes Research and Delivery Science (ACCORDS) University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma G.","family":"Beltran","sequence":"additional","affiliation":[{"name":"University of Colorado School of Medicine  Aurora Colorado 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