{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:43:29Z","timestamp":1790073809884,"version":"4.0.1"},"reference-count":52,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T00:00:00Z","timestamp":1718582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:p>We describe two cases of umbilical cord (UC) angiomyxoma diagnosed prenatally by sonography in the second trimester of pregnancy. In both cases, a complex mass was detected at the placental insertion site, characterized by an echoic nodule surrounding the umbilical vessels and distal edematous Wharton's jelly. Follow\u2010up scans showed that the mass grew mainly at the expense of its edematous component, with normal uteroplacental Dopplers throughout the remaining of the pregnancy. However, late\u2010onset fetal growth restriction complicated the progress of pregnancy, requiring delivery by Cesarean section at 37\u2009weeks' gestation in both cases. Neonatal courses were unremarkable. An extensive review of the English literature was also performed, collecting 45 similar cases including ours. Our experience as well as the review of the literature confirms that UC angiomyxoma is an uncommon, sporadic condition that is usually detected incidentally during prenatal sonography and presents as an isolated finding. Nevertheless, it represents a high\u2010risk condition for pregnancy complications including prematurity, fetal growth restriction, and fetal demise.<\/jats:p>","DOI":"10.1002\/jum.16506","type":"journal-article","created":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T09:54:40Z","timestamp":1718618080000},"page":"1769-1784","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prenatal Diagnosis of Umbilical Cord Angiomyxoma"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1231-9708","authenticated-orcid":false,"given":"Alexandra Pires","family":"Grossi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Nossa Senhora do Rocio Hospital  Campo Largo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriane Fischer","family":"Astori","sequence":"additional","affiliation":[{"name":"Instituto Feminino &amp; Fetal (IFF)  S\u00e3o Jos\u00e9 dos Pinhais Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson Tetsuya","family":"Nakatani","sequence":"additional","affiliation":[{"name":"Instituto da Mulher e Medicina Fetal (IMMEF)  Curitiba Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Jure","sequence":"additional","affiliation":[{"name":"Sonomed  San Fernando Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyana","family":"Salazar","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital Dr. Franco Ravera Zunino  Rancagua Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2620-7486","authenticated-orcid":false,"given":"Gabriele","family":"Tonni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Azienda USL \u2013 Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS)  Reggio Emilia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3856-574X","authenticated-orcid":false,"given":"Waldo","family":"Sepulveda","sequence":"additional","affiliation":[{"name":"FETALMED\u2014Maternal\u2010Fetal Diagnostic Center Fetal Imaging Unit  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"99","article-title":"Angiomyxoma of the umbilical cord with atrophy of an umbilical artery","volume":"30","author":"Benirschke K","year":"1967","journal-title":"Obstet Gynecol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-198003000-00022"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4193-3_8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-2592-4.50021-7"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513818309025870"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1990.9.5.297"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.01.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2006.25.11.1495"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1078\/0344-0338-00354"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0301-2"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(94)02297-c"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24755"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3468(97)90625-4"},{"key":"e_1_2_7_15_1","first-page":"935","article-title":"Angiomyxoma of the umbilical cord with massive cystic degeneration of Wharton's jelly","volume":"113","author":"Yavner DL","year":"1989","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1990.9.7.419"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90167-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3109\/15513811003796920"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.7656"},{"key":"e_1_2_7_20_1","first-page":"241","article-title":"Color Doppler ultrasound in prenatal diagnosis of umbilical cord angiomyxoma. 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