{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:29:14Z","timestamp":1747150154233,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the effect of intrahepatic cholestasis of pregnancy (ICP) on fetal heart morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2013control study was conducted with 40 women with ICP and 54 pregnant controls. Fetal heart quantification based on speckle tracking technology was used to assess the morphology of the fetal right and left ventricles. Routine ventricular size parameters, global and 24\u2010segment spherical indices (SIs) were measured and compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The routine fetal cardiac parameters, global and right\u2010ventricular SIs did not differ between the ICP and control groups. The left\u2010ventricular apical (segments 16\u201024) SIs were lower in the ICP group than in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), with no significant difference in the other left\u2010ventricular segments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Subclinical morphological changes were observed in the left ventricular apical segments of the fetal hearts in women with ICP, which indicates an intrauterine environment with high bile acid concentrations. Twenty\u2010four\u2010segment SIs can be used to effectively evaluate these changes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16554","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T12:49:51Z","timestamp":1724071791000},"page":"2187-2194","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Fetal Ventricular Size and Shape in Women With Intrahepatic Cholestasis of Pregnancy Using Speckle Tracking"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6966-1938","authenticated-orcid":false,"given":"Rui","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"He","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqin","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X18797749"},{"volume-title":"Pregnancy Intrahepatic Cholestasis","year":"2024","author":"Pillarisetty LS","key":"e_1_2_8_3_1"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.039"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.10.041"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs1000363"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2022.102013"},{"key":"e_1_2_8_8_1","first-page":"208","article-title":"Correlation of left ventricular remodeling, strain and systolic function in dilated cardiomyopathy by dot tracking technique","volume":"32","author":"Sun L","year":"2016","journal-title":"Chin J Ultrasound Med"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517625"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12947-021-00256-z"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14261"},{"key":"e_1_2_8_12_1","first-page":"1469","article-title":"Experimental study on the mechanism of myocardial damage in fetal rats with ICP","volume":"40","author":"Dong L","year":"2011","journal-title":"Shanxi Med J"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14455"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.19048"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051414"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.16554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T01:32:15Z","timestamp":1729042335000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.16554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,19]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1002\/jum.16554"],"URL":"https:\/\/doi.org\/10.1002\/jum.16554","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"type":"print","value":"0278-4297"},{"type":"electronic","value":"1550-9613"}],"subject":[],"published":{"date-parts":[[2024,8,19]]},"assertion":[{"value":"2024-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}