{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:49:11Z","timestamp":1786978151463,"version":"build-2736575974"},"reference-count":10,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to systematically investigate the ultrasonographic features of nodular hidradenoma (NH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was used to systematically summarize the ultrasonographic data of 27 patients diagnosed with NH by surgical pathology, including 13 eccrine nodular hidradenomas (ENH) and 14 apocrine nodular hidradenomas (ANH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All instances of NH presented as solitary, well\u2010defined lesions that infiltrated the dermis and subcutaneous fat layer, characterized by a heterogeneous hypoechoic internal solid component on ultrasound imaging. Color Doppler ultrasound revealed blood flow signals of Grade 2 or higher within 74% (20\/27) of the lesions. Solid + cystic (cystic &gt;50%) NH (14\/27, 51.4%) were typically large and predominantly had an oval shape (11\/14, 78.5%). Their distinctive sonographic features included the presence of inner septa within the cystic area (8\/14, 57.1%), \u201csnow falling\u201d sign (7\/14, 50%), or \u201cfluid\u2013fluid level\u201d sign (7\/14, 50%). Solid + cystic (cystic \u226450%) NH exhibited a lobulated morphology in all instances (5\/5, 100%). No inner septa, \u201csnow falling\u201d sign or \u201cfluid\u2013fluid level\u201d sign was observed within the cystic regions. The solid NH (8\/27, 29.7%) morphology predominantly featured lobulation (6 out of 8, 75%). Ultrasound analysis revealed distinct differences between ENH and ANH. ENH were more lobulated, while ANH were predominantly oval. ANH were mainly solid + cystic (cystic &gt;50%), whereas ENH were mostly solid. Inner septa, \u201csnow falling\u201d sign, and \u201cfluid\u2013fluid level\u201d sign frequencies were similar in both groups, correlating more with cystic\u2010solid composition than pathological subtype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ultrasonographic features of lobulated morphology and the presence of inner septa, \u201csnow falling\u201d sign or \u201cfluid\u2013fluid level\u201d sign in the cystic region provide strong support for the diagnosis of NH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.16569","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T08:35:56Z","timestamp":1725611756000},"page":"2411-2417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Ultrasound Features of Nodular Hidradenoma"],"prefix":"10.1002","volume":"43","author":[{"given":"Ming\u2010Chu","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital of Traditional Chinese Medicine  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0274-8883","authenticated-orcid":false,"given":"Jian\u2010Feng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital of Traditional Chinese Medicine  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Zhongshan Hospital of Traditional Chinese Medicine  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Cheng","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital of Traditional Chinese Medicine  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Mei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Zhongshan Hospital of Traditional Chinese Medicine  Zhongshan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2022.09.053"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2983"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.12720"},{"key":"e_1_2_6_5_1","first-page":"112","article-title":"Hidradenoma papilliferum: diagnostic challenge","volume":"151","author":"Campanati A","year":"2016","journal-title":"G Ital Dermatol Venereol"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441218"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14552"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14379"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.23554"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.07.003"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31821a4d33"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.16569","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T06:37:42Z","timestamp":1731479862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.16569"}},"subtitle":["A Case Series of 27 Patients"],"short-title":[],"issued":{"date-parts":[[2024,9,6]]},"references-count":10,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/jum.16569"],"URL":"https:\/\/doi.org\/10.1002\/jum.16569","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,6]]},"assertion":[{"value":"2024-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}