{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T14:29:12Z","timestamp":1771079352245,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The coexistence of intrauterine twin pregnancy and ectopic pregnancy (EP), known as heterotopic pregnancy, is a rare but potentially life\u2010threatening condition. In this study, we aimed to investigate the pregnancy outcomes in women with intrauterine twin pregnancies complicated with EP after assisted reproductive technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study analyzed the medical records of 42 women diagnosed with intrauterine twin pregnancies complicated with EP via ultrasound or surgery at our hospital between January 2005 and December 2020. We collected data on patient general characteristics, high\u2010risk factors, clinical symptoms, ultrasound features, treatment methods, and pregnancy outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 42 included women, 47.6% (20\/42) had a history of tubal surgery, while 52.4% (22\/42) and 47.6% (20\/42) received the transfer of 2 and 3 embryos, respectively. In terms of treatment, 21.4% (9\/42) women received expectant management, whereas 78.6% (33\/42) underwent surgical treatment, with laparoscopic surgery accounting for 71.4% (30\/42). Tracking the pregnancy outcomes revealed a live birth rate of 81.0% (34\/42) and a full\u2010term birth rate of 50.0% (21\/42). The preterm birth rate was 31.0% (13\/42), with a breakdown of 1 singleton (7.7%, 1\/13) and 12 twin births (92.3%, 12\/13) among the total 13 premature deliveries. Among the neonates, 33.3% (14\/42) were singletons and 47.6% (20\/42) twins. Caesarean section accounted for 31 out of 34 deliveries (91.2%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Though the incidence of EP in twin pregnancies has declined in the last decade, early diagnosis and proper management are still crucial for favorable outcomes in twin pregnancies with EP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jum.16583","type":"journal-article","created":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T06:59:00Z","timestamp":1727506740000},"page":"87-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diagnosis of 42 Cases of Intrauterine Twin Pregnancy Complicated With Ectopic Pregnancy"],"prefix":"10.1002","volume":"44","author":[{"given":"Mingxiang","family":"Zheng","sequence":"first","affiliation":[{"name":"Imaging Department Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya, Clinical Research Center for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Wen","sequence":"additional","affiliation":[{"name":"Imaging Department Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya, Clinical Research Center for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hengxu","family":"Wang","sequence":"additional","affiliation":[{"name":"Changsha Medical University  Changsha City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangqin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Science and Research Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya, Clinical Research Center for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gong","family":"Fei","sequence":"additional","affiliation":[{"name":"Reproductive Center Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya, Clinical Research Center for Reproduction and Genetics in Hunan Province  Changsha City China"},{"name":"NHC Key Laboratory of Human Stem Cell and Reproductive Engineering, School of Basic Medical Sciences Central South University  Changsha City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Hui","sequence":"additional","affiliation":[{"name":"Endoscope Center Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya, Clinical Research Center for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Imaging Department Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya, Clinical Research Center for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0986-760X","authenticated-orcid":false,"given":"Xihong","family":"Li","sequence":"additional","affiliation":[{"name":"Imaging Department Reproductive &amp; Genetic Hospital of CITIC\u2010Xiangya, Clinical Research Center for Reproduction and Genetics in Hunan Province  Changsha City China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.09.031"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1166446"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.6080"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-1208.39595"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-018-0316-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)54258-7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.1.80"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.502"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2013.02.004"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11596-014-1239-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12522-011-0098-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.06.037"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1577-z"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12341"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2017.07.015"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2010.501414"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.09.009"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmad030"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825af2f0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16103"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-017-4384-y"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-62311-5"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmt047"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.05.085"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.940111"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(97)70163-7"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001703-200208000-00003"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.16583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T17:47:29Z","timestamp":1733939249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.16583"}},"subtitle":["A Retrospective Cohort Study"],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/jum.16583"],"URL":"https:\/\/doi.org\/10.1002\/jum.16583","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]},"assertion":[{"value":"2024-07-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}