{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:53:34Z","timestamp":1792007614807,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T00:00:00Z","timestamp":1751068800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Hidradenitis suppurativa (HS) is a chronic inflammatory disease affecting hair follicles, significantly impacting patients' quality of life. While clinical assessment remains the cornerstone of diagnosis and staging, ultrasound (US) has emerged as a valuable tool for disease evaluation, treatment guidance, and monitoring. The introduction of ultra\u2010high frequency ultrasound (UHFUS) allowed for near in vivo histopathological examination of HS lesions. This study aimed to correlate UHFUS features with histopathological findings in HS lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three patients at different disease stages underwent pre\u2010surgical UHFUS mapping using a 70\u2009MHz linear probe. Regions of interest (ROIs) were identified and marked preoperatively. Patient 1 had an abscess and perilesional skin, Patient 2 had a draining abscess, and Patient 3 had a clinically evident tunnel. Local excision was performed for Patient 1, while wide excision was conducted for Patients 2 and 3. Tissue samples underwent histological examination, and UHFUS findings were analyzed by three independent observers in consultation with a pathology expert.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>UHFUS demonstrated the ability to delineate fluid collections, tunnels, and subclinical lesions with high precision. Case 1 revealed a fluid collection with an intra\u2010lesional drop\u2010shaped inclusion, corresponding histologically to a neutrophilic abscess with keratin\u2010filled cysts. Case 2 showed an elongated inclusion within a fluid collection, which histology confirmed as a keratin cyst linked to a tunnel. Case 3 exhibited a tunnel structure characterized by hyperechoic bands on UHFUS, correlating histologically with a keratinized epithelial\u2010lined tunnel.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>These findings highlight UHFUS as a non\u2010invasive tool enhancing HS assessment, bridging clinical and histopathological evaluation. Further research is needed to standardize parameters and optimize its clinical utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.16759","type":"journal-article","created":{"date-parts":[[2025,6,28]],"date-time":"2025-06-28T03:54:21Z","timestamp":1751082861000},"page":"2149-2156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Correlation Between Ultra\u2010High Frequency Ultrasound (\n                    <scp>UHFUS<\/scp>\n                    ) and Histological Features of Typical Lesions in Hidradenitis Suppurativa"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0795-0338","authenticated-orcid":false,"given":"Alessandra","family":"Michelucci","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"},{"name":"Interdisciplinary Center of Health Science Sant'Anna School of Advanced Studies of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giammarco","family":"Granieri","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Scatena","sequence":"additional","affiliation":[{"name":"Division of Pathology, Department of Translation Research on New Technologies in Medicine and Surgery University of Pisa  Pisa Italy"},{"name":"Department of Laboratory Medicine Pisa University Hospital, Anatomia Patologica 1 Universitaria  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Cei","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia Manzo","family":"Margiotta","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Pisa  Pisa 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