{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:46:22Z","timestamp":1772988382525,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to determine if omphalocele ratios can function as predictors of genetic abnormalities and to assess whether genetic anomalies influence postnatal surgical closure in pregnancies complicated by fetal omphalocele.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective study of pregnancies complicated by fetal omphalocele. Omphalocele size, ratios, and presence of extracorporeal liver were evaluated as predictors of abnormal genetic testing results. Surgical outcomes of subjects with identified genetic abnormalities were compared to those without genetic anomalies. Receiver operating curve analyses were performed to predict abnormal genetic testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Hundred and thirty\u2010nine fetal omphalocele cases were identified during the study period, with 56 cases included in this analysis. Abnormal genetic results were detected in 9 cases (16.1%). Omphalocele size cut\u2010offs and ratios were poor predictors of genetic abnormality. Patients with genetic findings were more likely to present with smaller omphaloceles. Primary closure occurred in 89% of neonates with a genetic abnormality versus 42.5% of neonates without a genetic anomaly (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.02).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While pregnancies with genetic abnormalities were associated with smaller lesions and higher rates of primary surgical closure, no lesion measurement performed well as a predictor of genetic abnormality. Our findings support offering genetic testing in all cases of fetal omphalocele, regardless of size.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.16764","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T05:23:12Z","timestamp":1751260992000},"page":"2113-2121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Fetal Genetic Abnormalities, Lesion Size, and Postnatal Outcomes Among Pregnancies Complicated by Fetal Omphalocele"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5354-3442","authenticated-orcid":false,"given":"Helen B.","family":"Gomez Slagle","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell S.","family":"Miller","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent P.","family":"Duron","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Columbia University Irving Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald J.","family":"Wapner","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Columbia University Irving Medical Center  New York NY USA"},{"name":"Division of Women's Genetics, Department of Obstetrics &amp; Gynecology Columbia University  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynn L.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noelle","family":"Breslin","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine Columbia University Irving Medical Center  New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.sempedsurg.2019.04.003"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000920"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.06.052"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.06.032"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.10.047"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.894"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-007-2034-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.1962966"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.158.1.1727339"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1028-4559(08)60099-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5930"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1989.8.6.299"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32042-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000323326"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2015.10.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.5546"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.894"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4578912"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(98)00170-5"},{"key":"e_1_2_8_21_1","first-page":"833","volume-title":"Fetology: Diagnosis and Management of the Fetal Patient","author":"Bianchi DW","year":"2010"},{"key":"e_1_2_8_22_1","first-page":"641","volume-title":"Fetal Imaging: Ultrasound and MRI","author":"Kline\u2010Fath BM","year":"2015"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.16764","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.16764","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.16764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:27:36Z","timestamp":1772969256000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.16764"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,30]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/jum.16764"],"URL":"https:\/\/doi.org\/10.1002\/jum.16764","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,30]]},"assertion":[{"value":"2024-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}