{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T23:08:55Z","timestamp":1779923335743,"version":"3.53.1"},"reference-count":14,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:p>Exosomes are extracellular vesicles that play a crucial role in intercellular communication and are becoming an increasingly popular worldwide aesthetic procedure. To date, the ultrasound changes in the cutaneous layers generated by exosomes have not been reported. We present 3 cases that were ultrasonographically studied before and 3\u2009months after the last exosome procedure, using high (24\u2009MHz) and ultra\u2010high (71\u2009MHz) frequencies. The exosome regions were compared with the contralateral (non\u2010treated) areas and adjacent tissues before and after application. Hyperechoic islets in the upper hypodermis and an increase in dermal vascularity were detected in these cases, forming a consistent pattern in the 3 cases at the exosome regions. This may be related to a mild degree of inflammation and neoangiogenesis in the treated regions. In 1 patient with alopecia, there was evidence of hair follicle growth at the exosome area. Further investigations are needed to examine the persistence of these changes over time and the impact of local trauma on the ultrasonographic abnormalities resulting from the application of these agents. The capability to identify ultrasonographic patterns in cutaneous exosomes may help discriminate them from abnormalities present in dermatologic diseases, particularly when patients do not provide a clear history, and monitor anatomical changes more objectively.<\/jats:p>","DOI":"10.1002\/jum.70000","type":"journal-article","created":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T12:21:02Z","timestamp":1752236462000},"page":"2355-2360","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Color Doppler Ultrasound Pattern of Cutaneous Exosomes at High and Ultra\u2010High Frequency"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3359-5023","authenticated-orcid":false,"given":"Ximena","family":"Wortsman","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine, Pontificia Universidad Catolica de Chile  Santiago Chile"},{"name":"Institute for Diagnostic Imaging and Research of the Skin and Soft Tissues  Santiago Chile"},{"name":"Department of Dermatology and Cutaneous Surgery, Miller School of Medicine University of Miami  Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natacha","family":"Quezada","sequence":"additional","affiliation":[{"name":"Department of Dermatology School of Medicine, Pontificia Universidad Catolica de Chile  Santiago Chile"},{"name":"Dermaline Center  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,11]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"33","article-title":"Exosomes: a comprehensive review for the practicing dermatologist","volume":"18","author":"Mahmoud RH","year":"2025","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.348"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147794"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reth.2024.10.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijd.ijd_491_23"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1161-8872"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ad.2013.11.015"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1203475421999326"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/RUQ.0000000000000520"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.14366\/usg.22130"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.15.06046"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.14888"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16000"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16481"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70000","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:52:13Z","timestamp":1762919533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,11]]},"references-count":14,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/jum.70000"],"URL":"https:\/\/doi.org\/10.1002\/jum.70000","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,11]]},"assertion":[{"value":"2025-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}