{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:22:23Z","timestamp":1791354143458,"version":"4.3.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The umbilical vein (UV) plays a crucial role in fetal oxygenation, and its dysfunction may contribute to adverse outcomes in small\u2010for\u2010gestational\u2010age (SGA) fetuses. We hypothesized that UV Doppler assessment could enhance risk stratification and guide delivery timing. This study compared UV hemodynamics between SGA and appropriate\u2010for\u2010gestational\u2010age (AGA) fetuses to evaluate their predictive value for low birth weight.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective cohort study (Tehran, Iran; July\u2013December 2024), we included singleton pregnancies &gt;32\u2009weeks. SGA was defined as estimated fetal weight (EFW) or abdominal circumference (AC) &lt;10th percentile, excluding fetal growth restriction (EFW\/AC &lt;3rd percentile or additional Doppler abnormalities). UV flow (UVF), EFW\u2010normalized UVF (nUVF), and UV diameters (intra\u2010abdominal and free\u2010loop) were compared between SGA and AGA cohorts. Predictive performance for low birth weight (&lt;2500\u2009g) was assessed via receiver operating characteristic (ROC) analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 322 pregnancies (78 SGA, 24.2%), SGA fetuses exhibited significantly lower UVF (172.1 versus 216.3\u2009mL\/min;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001), nUVF (76.4 versus 81.4\u2009mL\/minute\/kg;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u2009.048), and narrower UV diameters (both\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.001). After adjustment, differences persisted except for nUVF. UVF and UV diameters moderately predicted low birth weight (areas under the ROC curve [AUCs]\u2009&gt;\u2009.70), with free\u2010loop diameter showing the highest discrimination (AUC\u2009=\u2009.798, 95% confidence interval: 0.687\u20130.909).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SGA fetuses with normal umbilical artery Doppler demonstrate significant UV hemodynamic changes. UV Doppler, particularly free\u2010loop diameter, may help identify high\u2010risk pregnancies, aiding delivery planning. These findings support further exploration of UV assessment in SGA management protocols.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70007","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T10:35:31Z","timestamp":1754735731000},"page":"2257-2269","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Umbilical Vein Doppler Evaluation in Small\u2010for\u2010Gestational\u2010Age Fetuses With Normal Umbilical Artery Doppler Findings"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7764-0319","authenticated-orcid":false,"given":"Mohammadamin","family":"Parsaei","sequence":"first","affiliation":[{"name":"Breastfeeding Research Center, Family Health Research Institute Tehran University of Medical Sciences  Tehran 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Center, Family Health Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobina","family":"Taghva Nakhjiri","sequence":"additional","affiliation":[{"name":"Breastfeeding Research Center, Family Health Research Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Hamidi Madani","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Center, Department of Obstetrics and Gynecology, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Aliasgharpoor","sequence":"additional","affiliation":[{"name":"Vali\u2010e\u2010Ast Reproductive Health Research Center, Family Health Research Institute Tehran University of Medical Sciences  Tehran 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