{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:50:07Z","timestamp":1785419407759,"version":"3.56.0"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T00:00:00Z","timestamp":1754870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2025JJ50598"],"award-info":[{"award-number":["2025JJ50598"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ60410"],"award-info":[{"award-number":["2023JJ60410"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Accurate preoperative differentiation of benign and malignant parotid masses is crucial for determining appropriate treatment strategies. We aimed to investigate the value of combining conventional ultrasonography (US) with the measurement of sonoelastographic strain ratio (SR) for the preoperative differentiation of parotid masses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a single\u2010center retrospective study of 514 patients who had undergone excision of parotid gland masses from June 2019 to June 2023. Patients underwent preoperative high\u2010resolution imaging, which was performed to record SRs between lesional and peri\u2010lesional tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Histopathologic results disclosed benign lesions in 443 patients and malignant neoplasms in 71 patients. Pleomorphic adenoma and Warthin tumor were the most prevalent histopathologic diagnoses in the benign group. Prevalence rates of specific malignant tumor types did not differ significantly. Lesion shapes differed significantly between benign and malignant lesions, but border definition, echogenicity, and vascularization were similar. The sensitivity, specificity, accuracy, positive and negative predictive values, and diagnostic performance of US\u2009+\u2009SR, exceeded those of either US or SR alone. The optimal cutoff point (2.25) was computed by using receiver operating characteristics analysis (area under the curve 0.908). The sensitivity, specificity, and accuracy of the strain index values were 88.7, 83.8, and 84.2%, respectively, when the optimal cutoff point of 2.25 was used.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SR combined with US can more accurately differentiate benign from malignant parotid gland masses than either US or SR alone; and can thereby facilitate the optimal design of diagnostic and therapeutic interventions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70029","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T10:27:45Z","timestamp":1754908065000},"page":"85-94","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasonography Combined With Sonoelastography Strain Ratio for the Differentiation of Parotid Masses"],"prefix":"10.1002","volume":"45","author":[{"given":"Qun","family":"Li","sequence":"first","affiliation":[{"name":"Department of Stomatology The First Hospital of Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology The First Hospital of Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke\u2010Ping","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery The First Hospital of Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The First Hospital of Hunan University of Chinese Medicine  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Chun","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Chinaproducts Marketing Shenzhen Mindray Bio\u2010Medical Electronics Co. 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Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiong\u2010Jun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Equipment Division The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-269X","authenticated-orcid":false,"given":"Gui\u2010Xiang","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Ultrasound The Second Xiangya Hospital of Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cden.2012.05.013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.13002"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455727"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.9.929"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.12.015"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr.20210484"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1866-4633"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25936"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-013-1591-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-011-1745-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2010.0079"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2012.11349.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2011.10.026"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003300050576"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu-3123"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529310"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2022.103690"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1079-2104(99)70120-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2004.02.007"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2018.04.011"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu-3068"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2020.04.027"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1259\/dmfr\/60907848"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1258\/ar.2012.120405"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu.2013.2066.154.afb2"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4081\/reumatismo.2006.138"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3233\/ch-131732"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1299130"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13010012"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2401-x"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-018-5609-6"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T05:00:35Z","timestamp":1764651635000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,11]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jum.70029"],"URL":"https:\/\/doi.org\/10.1002\/jum.70029","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,11]]},"assertion":[{"value":"2025-07-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}