{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:35:15Z","timestamp":1784302515993,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,1]]},"abstract":"\n Background<\/jats:title>\n \n Detection of conotruncal anomalies in the first trimester remains challenging. Slow\n flow<\/jats:italic>\n HD, a Doppler modality with enhanced low\u2010flow sensitivity, may improve visualization of cardiac outflow tracts.\n <\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n \n To evaluate the utility of transabdominal Slow\n flow<\/jats:italic>\n HD in detecting conotruncal congenital heart defects (CHDs) during routine first\u2010trimester ultrasound screening.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Between January 2023 and April 2025, 1080 singleton pregnancies underwent ultrasound screening at 12\u2009+\u20090 to 13\u2009+\u20096\u2009weeks' gestation using the Voluson Expert 22 with an RM7C probe. Cardiac evaluation included grayscale imaging and monochrome, non\u2010directional Slow\n flow<\/jats:italic>\n HD of the four\u2010chamber view (4CV), left ventricular outflow tract (LVOT), and three\u2010vessel trachea view (3VT). HD\n live<\/jats:italic>\n \u2122 Flow was used to confirm flow direction when needed. All scans were transabdominal and performed by a single experienced operator. Suspected CHDs were referred for second\u2010trimester echocardiography or genetic testing.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Five fetuses were identified with outflow tract anomalies: tetralogy of Fallot (n\u2009=\u20093), double outlet right ventricle (n\u2009=\u20091), and transposition of the great arteries (n\u2009=\u20091). In all cases, Slow\n flow<\/jats:italic>\n HD provided clearer delineation of septo\u2010aortic continuity and vessel alignment than grayscale alone. Diagnoses were confirmed postnatally or during the second trimester; except in one case with trisomy 21, which was electively terminated.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Slow\n flow<\/jats:italic>\n HD enhances early detection of conotruncal anomalies by improving visualization of key vascular structures. This modality may serve as a useful adjunct to conventional imaging in first\u2010trimester screening. Further validation in larger cohorts is warranted.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jum.70037","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T11:59:46Z","timestamp":1755604786000},"page":"201-207","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["First\u2010Trimester Detection of Conotruncal Anomalies Using Transabdominal\n \n Slow\n flow<\/i>\n HD\n <\/scp>"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-3026","authenticated-orcid":false,"given":"Hirotsugu","family":"Fukuda","sequence":"first","affiliation":[{"name":"Aya Fukuda Ladies Clinic, Hirotsugu Prenatal Diagnosis Center Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aya","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Aya Fukuda Ladies Clinic, Hirotsugu Prenatal Diagnosis Center Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Mimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Osaka University Graduate School of Medicine Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Children and Women's Health Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko K.","family":"Pooh","sequence":"additional","affiliation":[{"name":"Fetal Diagnostic Center CRIFM Prenatal Medical Clinic Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Kodama","sequence":"additional","affiliation":[{"name":"Department of Children and Women's Health Osaka University Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.2642"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20844"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.10.037"},{"key":"e_1_2_8_5_1","volume-title":"A Practical Guide to Fetal Echocardiography: Normal and Abnormal Hearts","author":"Abuhamad A","year":"2016"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15928"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16085"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.26106"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23572"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10009-2054"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.29095"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16196"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.23740"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.6391"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.21988"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70037","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T05:00:21Z","timestamp":1764651621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70037"}},"subtitle":["A Case Series and Proof\u2010of\u2010Concept Study"],"short-title":[],"issued":{"date-parts":[[2025,8,19]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1002\/jum.70037"],"URL":"https:\/\/doi.org\/10.1002\/jum.70037","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,19]]},"assertion":[{"value":"2025-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}