{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T01:15:52Z","timestamp":1773018952266,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2024A04J4569"],"award-info":[{"award-number":["2024A04J4569"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801705"],"award-info":[{"award-number":["81801705"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study investigated risk factors for abnormally invasive placenta (AIP) in singleton pregnancies and developed a risk prediction model using clinical and basic ultrasound features for AIP screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 16,735 singleton pregnancies (with\/without AIP) delivering at the First Affiliated Hospital of Sun Yat\u2010sen University (2017\u20132021). Eighteen clinical and 3 basic ultrasound features were recorded. AIP was confirmed via placental pathology or intraoperative observations. The cohort was randomly split into development (70%) and validation (30%) sets. Univariate\/multivariate logistic analyses and multicollinearity tests identified AIP predictors. Three models (clinical\u2010only, basic ultrasound\u2010only, combined) were constructed; their performances were compared to select the final model, visualized as a nomogram. Model performance was evaluated using receiver operating characteristic curves (ROC), area under the curves (AUC), calibration curves, and decision curve analysis (DCA) (1000 bootstraps, 5\u2010fold cross\u2010validation).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AIP was confirmed in 161 cases (0.962%). Independent predictors included a history of placenta accreta spectrum (PAS), advanced maternal age, assisted reproductive technologies (ART), pre\u2010pregnancy obesity, placenta previa\/low\u2010lying placenta, and placental location (p\u2009&lt;\u20090.05). In the validation set, the combined model had an AUC of 0.844 (95% CI 0.775\u20130.913), versus 0.781 (95% CI 0.701\u20130.862) for basic ultrasound\u2010only and 0.698 (95% CI 0.626\u20130.770) for clinical\u2010only. The nomogram of the combined model showed good discrimination; calibration curves and DCA confirmed satisfactory calibration and clinical utility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The combined clinical\u2010basic ultrasound model outperforms single\u2010component models in AIP prediction. Its nomogram has good predictive performance, enabling clinicians to quickly screen high\u2010risk pregnant women for AIP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70108","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T12:12:43Z","timestamp":1762949563000},"page":"805-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Primary Screening Predictive Model for Abnormally Invasive Placenta Based on Clinical and Basic Ultrasound Factors in Singleton Pregnancies"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-4505-9178","authenticated-orcid":false,"given":"Zhijun","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Ultrasonic Medicine, Fetal Medical Center First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine, Fetal Medical Center First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manwen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine, Fetal Medical Center First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meifang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine, Fetal Medical Center First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1705-1328","authenticated-orcid":false,"given":"Hongning","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Ultrasonic Medicine, Fetal Medical Center First Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(97)70463-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.Aog.0000219750.79480.84"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.01.233"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0252654"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.02.016"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.035"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002983"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2008.27.9.1275"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2020.0580"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8827"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.037"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.12.074"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dez079"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2008.02037.x"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e318262e340"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244-022-01192-w"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.24861"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12112769"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2021.2001800"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinsp.2022.100027"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9527412"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2022.09.021"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12761"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.12408"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13238"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2023.102262"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1442429"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2022.06.009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2014.955004"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052893"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.02976.x"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12080"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.05.006"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002434"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000004204"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.28002"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2020-0141"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina56010032"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.09.025"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.04.026"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719115592712"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-012-2450-z"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.07.028"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-021-01348-6"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2023.111116"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14420"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.14710"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2023.101174"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.70108","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:21:11Z","timestamp":1773015671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,12]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/jum.70108"],"URL":"https:\/\/doi.org\/10.1002\/jum.70108","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,12]]},"assertion":[{"value":"2025-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}