{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T21:24:47Z","timestamp":1785533087942,"version":"3.56.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007606","name":"Aarhus Universitetshospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate a scoring system using transvaginal ultrasound (TVS) to predict high\u2010risk endometrial cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Consecutive patients with endometrial cancer\/atypical hyperplasia (n\u2009=\u2009266) were preoperatively examined by residents using TVS. Clinical parameters, endometrial morphology and Doppler scores were recorded using a gray scale and Doppler TVS and related to final histopathology at hysterectomy. Multivariate logistic regression was used to correlate imaging and clinical parameters to the presence of high\u2010risk endometrial cancer (defined as FIGO stage Ib\u2010IV or high\u2010grade tumors [grade 3\/non\u2010endometroid]) to develop the High\u2010Risk Endometrial Cancer (HIREC) score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>High\u2010risk endometrial cancer (n\u2009=\u2009128) and lympho\u2010vascular space invasion (LVSI) (n\u2009=\u200943) were predicted by increased endometrial thickness (ET), age, and Doppler score. The HIREC scoring system, based on age, Doppler score, and ET performed well with an AUC of 78.5% (CI 95%: 73\u201384) to predict high\u2010risk cancer. By using a 2\u2010step strategy of (1) Preoperative identification of high\u2010grade tumors by biopsy, (2) Assessing the HIREC score, high\u2010risk endometrial cancer could be predicted at a HIREC score of \u22657 with sensitivity, specificity, and accuracy of 72.7, 88.4, and 80.8%. Low\u2010risk endometrial cancer was predicted at HIREC scores of &lt;5 with sensitivity, specificity, and accuracy values of 91.4, 46.4 and 68.1%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Low and high HIREC scores effectively predicted low\u2010 and high\u2010risk endometrial cancer. The score is a simple point system suitable for the first ultrasound assessment. It may be used in preoperative work\u2010up to select treatment and additional imaging, but it needs to be validated in further studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70113","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T09:49:46Z","timestamp":1764668986000},"page":"849-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasound Scoring to Predict High\u2010Risk Endometrial Cancer"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-2465","authenticated-orcid":false,"given":"Ina Marie Dueholm","family":"Hjorth","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5865-2939","authenticated-orcid":false,"given":"Line 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