{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:00:40Z","timestamp":1787857240634,"version":"build-2784847793"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to develop a multimodal model that integrates habitat radiomics and clinical features for non\u2010invasive prediction of axillary sentinel lymph node (SLN) metastasis in breast cancer (BC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed ultrasound images and clinical data from 191 female patients with BC treated at Beijing Luhe Hospital, Capital Medical University from May 2023 to January 2025. Patients were randomly assigned to training and test sets at a 7:3 ratio. Four models were constructed: a traditional radiomics model, a clinical model, a habitat model characterizing the tumor microenvironment, and a multimodal model combining habitat radiomics with clinical features. Model performance was assessed using receiver operating characteristic curve analysis and decision curve analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the training set, the habitat model achieved an area under the curve (AUC) of 0.869, outperforming the clinical model (AUC\u2009=\u20090.718) and the traditional radiomics model (AUC\u2009=\u20090.771). The multimodal model, integrating habitat analysis and clinical features, yielded the highest AUC (0.900). In the test set, the habitat model again showed superior discriminative ability (AUC\u2009=\u20090.866) compared with the clinical model (AUC\u2009=\u20090.727) and the radiomics model (AUC\u2009=\u20090.662); meanwhile, the multimodal model achieved the highest AUC (0.902).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The habitat model demonstrated superior predictive performance compared with models based solely on ultrasound radiomics or clinical features, and the multimodal approach yielded the best overall accuracy. This combined model offers a promising non\u2010invasive tool for pre\u2010operative assessment of SLN status in patients with BC and may assist clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70129","type":"journal-article","created":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T06:01:11Z","timestamp":1764309671000},"page":"947-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Ultrasound Habitat Radiomics Plus Clinical Features for Pre\u2010Operative Prediction of Sentinel Lymph Node Metastasis in Breast Cancer"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4299-4106","authenticated-orcid":false,"given":"Yiwei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Ultrasound in Medicine Beijing Luhe Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Beijing Luhe Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Beijing Luhe Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Beijing Luhe Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manyu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Beijing Luhe Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine Beijing Luhe Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12619-6"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1607442"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.884599"},{"key":"e_1_2_7_5_1","first-page":"436","article-title":"Factors affecting sentinel lymph node metastasis in Turkish breast cancer patients: predictive value of Ki\u201067 and the size of lymph node","volume":"117","author":"Ozemir IA","year":"2016","journal-title":"Bratisl Lek Listy"},{"key":"e_1_2_7_6_1","first-page":"217","article-title":"Ultrasound for breast cancer detection: a bibliometric analysis of global trends between 2004 and 2024","volume":"27","author":"Sun YY","year":"2025","journal-title":"Med Ultrason"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2017.03.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2219-x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2013-201524"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.757111"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2020.10.015"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40644-020-00342-x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122697"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S511796"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-024-01921-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2025.01.014"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2020.109512"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.754843"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-08855-8"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2024.106980"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2023.11.038"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-66751-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.29796"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2012.08.007"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hys150"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0359-y"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102176"},{"key":"e_1_2_7_28_1","first-page":"121","article-title":"Optimized radiomics nomogram based on automated breast ultrasound system: a potential tool for pre\u2010operative prediction of metastatic lymph node burden in breast cancer","volume":"15","author":"Li N","year":"2023","journal-title":"Breast Cancer (Dove Med Press)"},{"key":"e_1_2_7_29_1","article-title":"Radiomics to differentiate malignant and benign breast lesions: a systematic review and diagnostic test accuracy meta\u2010analysis","volume":"15","author":"Oh KE","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1323452"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1546229"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4264"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-99701-2"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604-024-01639-8"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1504132"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000245472.47748.ec"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cai2.70000"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2015.07.028"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15845"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.948767"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70129","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.70129","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:04:01Z","timestamp":1775534641000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/jum.70129"],"URL":"https:\/\/doi.org\/10.1002\/jum.70129","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"2025-09-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}