{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T14:06:30Z","timestamp":1781273190574,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the value of transitional phase characteristics on Sonazoid contrast\u2010enhanced ultrasound (S\u2010CEUS) in the differential diagnosis of common focal liver lesions (FLLs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This prospective multicenter study enrolled 122 participants with FLLs from 8 medical centers between December 2023 and March 2025. The study comprised 43 cases of hepatic hemangioma (HH), 35 cases of hepatocellular carcinoma (HCC), and 44 cases of liver metastases (LM). All participants underwent standardized S\u2010CEUS examinations. The enhancement characteristics and washout patterns during the transitional phase were analyzed for all participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Significant differences were observed among the three types of lesions in terms of early arterial enhancement patterns, time to start of washout, and the degree of enhancement during the transitional phase (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01). The optimal diagnostic efficacy was achieved with the following criteria: washout start at 3.5\u2009min for diagnosing HH (AUC\u2009=\u20090.974); mild hypoenhancement observed in 3 and 4\u2009min for diagnosing HCC (AUC\u2009=\u20090.880 and 0.879); and marked hypoenhancement observed between 4 and 6\u2009min for diagnosing LM (AUC\u2009=\u20090.911\u20130.916).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The dynamic characteristics of the transitional phase in S\u2010CEUS can effectively differentiate common FLLs, providing a valuable basis for precise clinical diagnosis.<\/jats:p>\n                  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