{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T10:46:55Z","timestamp":1788778015470,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T00:00:00Z","timestamp":1766534400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071942"],"award-info":[{"award-number":["82071942"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      To evaluate the clinical application value of ultra micro angiography (\n                      <jats:styled-content style=\"fixed-case\">UMA<\/jats:styled-content>\n                      ) in noninvasively differential diagnosis between benign and malignant renal tumors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In this retrospective study, 65 patients diagnosed with solid renal tumors and intended for surgical resection in our hospital between December 2023 and March 2025 were enrolled. All patients underwent B mode ultrasound, color Doppler flow imaging (\n                      <jats:styled-content style=\"fixed-case\">CDFI<\/jats:styled-content>\n                      ) and\n                      <jats:styled-content style=\"fixed-case\">UMA<\/jats:styled-content>\n                      1\u2009week before surgery resections. Adler semiquantitative analysis (Grades 0\u20133) and vascular morphology (patterns A\u2013F) were used to assess the blood flow within the renal tumors. Based on histopathological results after surgery, patients were divided into benign and malignant groups. Using high\u2010level blood flow signals (Grades 2 and 3) and hypervascular supply (patterns E and F) as diagnostic criteria for malignant renal tumors, the diagnostic efficiency of\n                      <jats:styled-content style=\"fixed-case\">CDFI<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">UMA<\/jats:styled-content>\n                      were analyzed and compared.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      According to surgical resection and histopathological results, patients were divided into benign group (n\u2009=\u200910) and malignant group (n\u2009=\u200955). On\n                      <jats:styled-content style=\"fixed-case\">UMA<\/jats:styled-content>\n                      , vascular morphology patterns and Adler grades in malignant group were significantly higher than those in benign group (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05). More high\u2010level blood flow signals and more complex vascular morphology patterns were detected by\n                      <jats:styled-content style=\"fixed-case\">UMA<\/jats:styled-content>\n                      than\n                      <jats:styled-content style=\"fixed-case\">CDFI<\/jats:styled-content>\n                      for malignant renal tumors (91.3% vs. 54.4%, 64.9% vs. 19.3%), with the area under curve of characteristics of 0.71 vs. 0.59, and 0.73 vs. 0.50, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      By sensitively displaying tiny and low\u2010velocity blood flow signals,\n                      <jats:styled-content style=\"fixed-case\">UMA<\/jats:styled-content>\n                      has potential value in preoperative noninvasively differential diagnosis between benign and malignant renal tumors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70165","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T11:47:09Z","timestamp":1766576829000},"page":"1247-1255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Application of Ultra Micro Angiography in Differential Diagnosis of Renal Tumors"],"prefix":"10.1002","volume":"45","author":[{"given":"Rui","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010quan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010si","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5268-0886","authenticated-orcid":false,"given":"Xiu\u2010wu","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shao\u2010jun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010lin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0920-9439","authenticated-orcid":false,"given":"Xin\u2010gang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Urology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0212-1477","authenticated-orcid":false,"given":"Yi","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-231750"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-09391-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-21-248"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2022.03.006"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2019.08.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0586-1107"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2023.11.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-136"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.15403\/jgld-5495"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2021.109567"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims-23-711"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-5629(90)90020-D"},{"key":"e_1_2_8_14_1","article-title":"The value of superb microvascular imaging in differentiating benign renal mass from malignant renal tumor: a retrospective study","volume":"91","author":"Mao Y","year":"2018","journal-title":"Br J Radiol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-221682"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/35025220"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.21037\/gs-20-641"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81914-0"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2024.04.026"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-87930-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-021-03214-2"},{"key":"e_1_2_8_22_1","first-page":"1215","article-title":"Application value of superb microvascular imaging for diagnosis of different size renal solid tumors","volume":"43","author":"Zhang D","year":"2021","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547-023-01679-6"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.213303"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pacs.2021.100302"},{"key":"e_1_2_8_26_1","first-page":"1778","article-title":"Comparative analysis of superb microvascular imaging and contrast\u2010enhanced ultrasound in diagnosis of small renal masses","volume":"99","author":"Zhang D","year":"2019","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.15299"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70165","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.70165","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:32:24Z","timestamp":1778110344000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,24]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jum.70165"],"URL":"https:\/\/doi.org\/10.1002\/jum.70165","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,24]]},"assertion":[{"value":"2025-09-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}