{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:21:10Z","timestamp":1791591670032,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To analyze the clinical and imaging characteristics of gastric\u2010type endocervical adenocarcinoma (GEA) with the aim of enhancing sonographers' awareness and early diagnostic proficiency regarding this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 9 patients with pathologically confirmed GEA treated at our institution between 2021 and 2024. The study involved a systematic evaluation of clinical manifestations along with transvaginal ultrasonography and magnetic resonance imaging (MRI) characteristics, aiming to analyze the relationship between clinical features and imaging findings in this disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Clinical characteristics<\/jats:italic>\n                      : Nine patients were included. The patients' ages ranged from 28 to 52\u2009years (mean 45.7\u2009\u00b1\u20098.5). Chief complaints were isolated watery vaginal discharge (4 cases), watery discharge with pelvic pain (1 case), watery discharge with post\u2010coital bleeding (2 cases), and lower\u2010abdominal pain alone (2 cases). HPV screening results were negative in 8 cases, with 1 case positive for HPV type 56. Thin\u2010prep cytology test (TCT) results were negative in 7 cases; 1 case showed atypical glandular cells (suspected cervical origin), and 1 case indicated a few high\u2010grade squamous intraepithelial lesions (HSIL). Gynecological examination revealed cervical hypertrophy with erosion (5 cases), hypertrophy with induration (2 cases), a smooth cervix with mild erosion (1 case), and a normal\u2010size, smooth cervix (1 case). Colposcopy and cervical biopsy indicated: adenocarcinoma (3 cases), suspicious abnormalities (2 cases), CIN I (2 cases), and chronic cervicitis (2 cases). Pre\u2010operative tumor markers: isolated elevation of CA 19\u20109 (2 cases), concomitant elevation of CA 19\u20109 and CA 125 (4 cases), and normal values for both markers (3 cases). The duration from symptom onset to diagnosis was \u22651\u2009year in 5 cases.\n                      <jats:italic>Imaging findings<\/jats:italic>\n                      : All patients underwent preoperative transvaginal ultrasound examination. The findings were as follows: abnormal cervical echogenicity (3 cases), cervical cancer involving the parametrium (2 cases), a cervical polyp (1 case), a cervical cyst (1 case), and no abnormality was detected in 1 case. Eight patients subsequently underwent pelvic MRI. Among these, 5 examinations were reported as malignant cervical neoplasm, 1 as endometrial carcinoma, 1 as suspicious thickening of the endocervical mucosa, and no appreciable mass was found in 1 case.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>GEA is characterized by an occult location, low rate of early detection, aggressive behavior, and poor prognosis. Nevertheless, its clinical presentation and imaging findings remain recognizable. In patients who present with persistent, profuse, watery vaginal discharge, careful evaluation of the upper and middle segments of the endocervical canal during gynecological examination and transvaginal ultrasonography is essential to improve early detection and minimize diagnostic omission.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70173","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T07:35:26Z","timestamp":1767512126000},"page":"1289-1296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinical and Imaging Features of Gastric\u2010Type Endocervical Adenocarcinoma"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-7689","authenticated-orcid":false,"given":"Jiao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruhui","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiology Affiliated Hospital of North Sichuan Medical College  Nanchong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2020200013"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2024.02.024"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000532"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359251361880"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13995"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000213434.91868.b0"},{"key":"e_1_2_8_8_1","volume-title":"WHO Classification of Tumours:Female Genital Tumours","author":"WHO Classification of Tumours Editorial Board","year":"2020"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001275"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"StolnicuSMD BarsanIMD.International Endocervical Adenocarcinoma Criteria and Classification (IECC): a new pathogenetic classification for invasive adenocarcinomas of the endocervix.2018;42:214\u2013226.","DOI":"10.1097\/PAS.0000000000000986"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13993"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-022-03724-w"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315022"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14602"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1457253"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2006.12.001"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S399986"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.modpat.2024.100569"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-021-08792-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0824-0"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1572438"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000000229"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2018.0458"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.70173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T23:32:32Z","timestamp":1778110352000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70173"}},"subtitle":["A Report of 9 Cases with Literature Review"],"short-title":[],"issued":{"date-parts":[[2026,1,3]]},"references-count":22,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/jum.70173"],"URL":"https:\/\/doi.org\/10.1002\/jum.70173","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,3]]},"assertion":[{"value":"2025-10-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}