{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:57:38Z","timestamp":1781153858235,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:00:00Z","timestamp":1768003200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate the value of the thickness of the frontal lobe (TFL) and foramen magnum\u2010to\u2010cranium distance (FCD) for predicting poor neurodevelopmental outcomes in fetuses with a small head circumference (HC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study included 39 fetuses with HC\u2009&lt;\u2009\u22122 standard deviations (SD) and 592 prospectively collected controls with normal growth. TFL was defined as the shortest distance between the upper outer border of the corpus callosum and the upper inner cranial border parallel to the FCD. Reference ranges for FCD and TFL were established in 592 healthy fetuses between 21 and 38\u2009weeks of gestation and applied to fetuses with suspected microcephaly. Diagnostic performance was assessed using sensitivity, specificity, and SD\u2010based thresholds.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Normal reference ranges for FCD and TFL across gestation were established. All fetuses with normal postnatal outcomes had TFL values within the normal range, whereas reduced TFL was observed only in fetuses with poor neurodevelopmental outcomes. For predicting adverse outcomes, TFL &lt;\u22122 SD showed a specificity of 100%, compared with 88% for FCD &lt;\u22122 SD. Combining HC &lt;\u22122 SD with TFL &lt;\u22122 SD improved identification of fetuses with poor outcomes, including cases with borderline HC measurements (\u22122 to \u22123 SD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When combined with HC, reduced TFL may serve as a highly specific prenatal marker for identifying fetuses at risk for adverse neurodevelopmental outcomes in suspected microcephaly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70177","type":"journal-article","created":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T11:05:27Z","timestamp":1768043127000},"page":"1409-1418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Novel Fetal Intracranial Measurement Contributing to the Differential Diagnosis of Fetal Microcephaly"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3217-9082","authenticated-orcid":false,"given":"Xi","family":"Du","sequence":"first","affiliation":[{"name":"National Center for Healthcare Quality Management in Obstetrics  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"State Key Laboratory of Female Fertility Promotion Department of Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education  Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HongJia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Sichuan Jinxin Xinan Women &amp; Children Hospital  Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Ultrasonography Changzhi Maternal &amp; Child Health Care Hospital  Changzhi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LinLin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Hefei Women and Children\u2019s Healthcare Hospital  Hefei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YiNan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"XinLin","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JunYa","family":"Chen","sequence":"additional","affiliation":[{"name":"National Center for Healthcare Quality Management in Obstetrics  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"State Key Laboratory of Female Fertility Promotion Department of Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University) 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