{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T04:57:39Z","timestamp":1781153859595,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The morphological alterations of the tibial nerve in patients with diabetes mellitus, both with and without diabetic peripheral neuropathy (DPN), are challenging to differentiate using B\u2010mode ultrasound. In this study, we assessed the stiffness changes of the tibial nerve by 2\u2010dimensional shear\u2010wave elastography (2D\u2010SWE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We gathered data from 70 adults with valid 2D\u2010SWE measurements, comprising 25 individuals in DPN Group A who were diagnosed with DPN and had peripheral nerve symptoms in the past 6\u2009months, 15 individuals in DPN Group B who were diagnosed with DPN but had no peripheral nerve symptoms in the past 6\u2009months, 16 individuals with type 2 diabetes but without DPN, and 14 healthy individuals. The maximal thickness, cross\u2010sectional area, and stiffness of the tibial nerve among groups were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      DPN Group A had higher tibial nerve stiffness than Group B, non\u2010DPN, and control groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.05). The area under the curve (AUC) for 2D\u2010SWE parameters in detecting increased nerve stiffness was 0.956 for G\n                      <jats:sub>1<\/jats:sub>\n                      (mean stiffness) and 0.979 for G\n                      <jats:sub>3<\/jats:sub>\n                      (distal stiffness), respectively, with optimal cut\u2010off values of 20.01 and 28.41\u2009kPa.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>2D\u2010SWE is a promising non\u2010invasive technique for early diagnosis of DPN, effectively reflecting changes in nerve stiffness associated with the condition. This method may enhance clinical interventions aimed at preventing disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70191","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:00:38Z","timestamp":1769774438000},"page":"1467-1475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Value of 2\u2010Dimensional Shear\u2010Wave Elastography in Assessing Tibial Nerve Stiffness in Diabetic Peripheral Neuropathy"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9943-5625","authenticated-orcid":false,"given":"Jiafan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound The Second Affiliated Hospital of Shantou University Medical College  Shantou 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