{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:42:54Z","timestamp":1791549774777,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Fetal growth restriction (FGR), commonly caused by placental insufficiency, is a critical obstetric condition requiring accurate and timely detection to mitigate adverse outcomes. Placental sonoelastography, an advanced ultrasound technique that evaluates tissue stiffness, has emerged as a promising tool for assessing placental health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A systematic review and meta\u2010analysis was conducted following PRISMA guidelines to evaluate the usefulness of placental elastography in FGR. We performed a comprehensive search of PubMed, Embase, Scopus, and Web of Science up to January 2025 for in\u2010vivo studies comparing placental elastography in the FGR and healthy control groups. Data from the included studies were pooled using random\u2010effects models to calculate standardized mean differences (SMD) and mean differences (MD) in placental stiffness. Additionally, correlation coefficients were pooled, and diagnostic accuracy metrics, including sensitivity and specificity, were synthesized using a bivariate random\u2010effects model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 14 studies were included in the systematic review. The meta\u2010analysis revealed significantly increased placental stiffness in FGR pregnancies. For Young's modulus, the pooled analysis of 9 studies yielded an SMD of 2.51 (95% CI: 0.72\u20134.30). For shear wave velocity, the pooled analysis of 6 studies revealed an SMD of 1.55 (95% CI: 0.83\u20132.28). Significant heterogeneity was noted in these analyses. Pooled data from 3 studies demonstrated a significant negative correlation between placental stiffness and birth weight (\n                      <jats:italic>r<\/jats:italic>\n                      \u2009=\u2009\u22120.453). The diagnostic accuracy, assessed from 4 studies, was high, with a pooled sensitivity of 92.0% and specificity of 98.9%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>Placental sonoelastography stands out as a powerful, non\u2010invasive technique that could significantly enhance the clinical assessment and surveillance of pregnancies at risk for FGR, potentially leading to more timely and effective interventions. This quantitative measure not only distinguishes FGR cases from healthy pregnancies with high accuracy but also correlates with meaningful neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70214","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:46:59Z","timestamp":1772988419000},"page":"1663-1676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Placental Stiffness Measured by Sonoelastography in Fetal Growth Restriction"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-9535","authenticated-orcid":false,"given":"Amirmohammad","family":"Azizzadeh","sequence":"first","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7340-4805","authenticated-orcid":false,"given":"Dorsa","family":"Shekouh","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parnia","family":"Jochin","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Babaei","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0138-8727","authenticated-orcid":false,"given":"Ehsan","family":"Mirzaaghazadeh","sequence":"additional","affiliation":[{"name":"Student Research Committee Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6652-7759","authenticated-orcid":false,"given":"Fahimeh","family":"Zeinalkhani","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Science  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman Kamali","family":"Hakim","sequence":"additional","affiliation":[{"name":"Advanced Diagnostic and Interventional Radiology Research Center (ADIR) Tehran University of Medical Science  Tehran Iran"},{"name":"Department of Radiology Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2021.02.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00033"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms150916153"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.15537\/smj.2015.8.11533"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13522"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1365.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.15884"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-021787"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2022.02.022"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12891-024-07351-y"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.845549"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00261-025-05159-5"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.18650"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15010047"},{"key":"e_1_2_9_17_1","doi-asserted-by":"crossref","unstructured":"DurhanG \u00dcnverdiH DeveciC B\u00fcy\u00fck\u015fireciM KarakayaJ De\u011firmenciT.Placental elasticity and histopathological findings in Normal and intra\u2010uterine growth restriction pregnancies assessed with strain elastography in ex vivo placenta.2017;43:111\u2013118.","DOI":"10.1016\/j.ultrasmedbio.2016.08.037"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13182894"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2025.112055"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpm-2019-0238"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2024.110329"},{"key":"e_1_2_9_22_1","doi-asserted-by":"crossref","unstructured":"AnukAT TanacanA ErolSA AlkanM AltinbogaO CelenS.Value of shear\u2010wave elastography and cerebral\u2013placental\u2013uterine ratio in women diagnosed with preeclampsia and fetal growth restriction in prediction of adverse perinatal outcomes.2022;35:10001\u201310009.","DOI":"10.1080\/14767058.2022.2081804"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejrad.2017.10.007"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.21649\/akemu.v27i4.4888"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13154432"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05596-1"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.2478\/raon-2018-0024"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43055-020-00246-7"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.47391\/JPMA.9314"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.33309\/2639-913X.020203"},{"key":"e_1_2_9_31_1","first-page":"2084","article-title":"Role of placenta shear\u2010wave elastography in assessment of intrauterine growth restriction: a retrospective study","volume":"16","author":"Kumar U","year":"2024","journal-title":"Int J Pharm Clin Res"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-023-01826-z"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.06.008"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000001203"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000004251"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ogc.2019.10.008"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.577"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-018-2019-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"crossref","unstructured":"CalleS DumouxM\u2010C NicolasE RemenierasJ\u2010P SimonE PerrotinF.Ex vivo measurement of shear wave speed dispersion in placenta using transient elastography. 2015 IEEE International Ultrasonics Symposium (IUS) 2015: 1\u20134.","DOI":"10.1109\/ULTSYM.2015.0178"},{"key":"e_1_2_9_40_1","doi-asserted-by":"crossref","unstructured":"DeebaF HuR LessowayV TerryJ PugashD HutcheonJ.SWAVE 2.0 imaging of placental elasticity and viscosity: potential biomarkers for placenta\u2010mediated disease detection.2022;48:2486\u20132501.","DOI":"10.1016\/j.ultrasmedbio.2022.08.001"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.5812\/iranjradiol.68280"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.70293"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.11.009"},{"key":"e_1_2_9_44_1","doi-asserted-by":"crossref","unstructured":"IssaouiM MiloroP BalandraudX et al.Temperature elevation in an instrumented phantom insonated by B\u2010mode imaging pulse doppler and shear wave elastography.2020;46:3317\u20133326.","DOI":"10.1016\/j.ultrasmedbio.2020.08.021"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diii.2018.04.013"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13383"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13382"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10110967"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2023.2203792"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.70214","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:49:00Z","timestamp":1783831740000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70214"}},"subtitle":["A Systematic Review and Meta\u2010Analysis"],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":48,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jum.70214"],"URL":"https:\/\/doi.org\/10.1002\/jum.70214","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}