{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:53:35Z","timestamp":1792500815867,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM 103652"],"award-info":[{"award-number":["P20 GM 103652"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005834","name":"Francis Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005834","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The venous excess ultrasound (VExUS) can be used at the point\u2010of\u2010care to identify venous overload and end\u2010organ congestion in an effort to individually tailor resuscitation and deresuscitation in patients with septic shock.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a pilot randomized controlled feasibility trial of VExUS\u2010guided fluid management in adult patients with septic shock. Participants were randomized to VExUS\u2010guided fluid management or usual care. Daily ultrasounds were performed on all participants; in the VExUS\u2010guided study arm, the clinical care team was informed of the VExUS results and given a fluid management recommendation (the intervention).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We enrolled 19 participants; 12 (63%) were randomized to the VExUS arm. The intervention period fluid balance was \u221265\u2009mL (interquartile range [IQR] \u22121733 to 2016) in the VExUS arm compared to 2608\u2009mL (IQR \u2212435 to 4460) in the usual care arm (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.21). The secondary outcomes of acute kidney injury, respiratory failure, hospital, and 30\u2010day mortality did not differ significantly between the 2 arms; although the rates were lower in the VExUS arm.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We demonstrate that VExUS\u2010guided fluid management in patients with septic shock is feasible, was not associated with an increased risk of adverse events, and may reduce the volume of fluids administered.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70219","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:06:11Z","timestamp":1773137171000},"page":"1685-1693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deresuscitation Informed by Ultrasound in Patients With Septic Shock Trial"],"prefix":"10.1002","volume":"45","author":[{"given":"Brendan","family":"Innes","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine, Division of Emergency Critical Care Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary and Critical Care Medicine University of Massachusetts Bay State  Springfield Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0486-6847","authenticated-orcid":false,"given":"Nicholas","family":"Seidler","sequence":"additional","affiliation":[{"name":"Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burton","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care &amp; Sleep Medicine Boston University Chobanian &amp; Avedisian School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Fried","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Maine Medical Center  Portland Maine USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Phillips","sequence":"additional","affiliation":[{"name":"Ohio State University Medical Center Center for Biostatistics  Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Levinson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care &amp; Sleep Medicine Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7887-243X","authenticated-orcid":false,"given":"Adeel","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Pulmonary, Critical Care &amp; Sleep Medicine Warren Alpert Medical School of Brown University  Providence Rhode Island USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000005337"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181feeb15"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-016-4675-y"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0000000000000268"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-014-0021-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-016-0231-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002189"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000006135"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2202707"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212663"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.04.036"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062200"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-023-07174-w"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.01.009"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.22559"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13089-020-00163-w"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/echo.15697"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2023.09.029"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.5492\/wjccm.v10.i6.310"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-023-04471-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw164"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-04961-9"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0009-9260(05)80001-7"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13089-019-0146-3"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.297095715"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0970-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2018.09.028"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00380-018-1117-5"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2015.09.012"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2016.03.016"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.05.006"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06506-y"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70219","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.70219","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70219","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:48:55Z","timestamp":1783831735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70219"}},"subtitle":["A Pilot Randomized Controlled Study"],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1002\/jum.70219"],"URL":"https:\/\/doi.org\/10.1002\/jum.70219","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"assertion":[{"value":"2025-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}