{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:28:25Z","timestamp":1787171305648,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Accessory breast tissue often presents as localized axillary subcutaneous fullness, presenting as a palpable soft\u2010tissue bulge composed of adipose or glandular elements, causing mechanical discomfort and esthetic concern. While surgical excision remains effective, it ma result in scarring, postoperative pain, and risks of seroma\/hematoma or contour irregularity, leading to growing interest in noninvasive approaches. The objective of the study is to investigate the effect of noninvasive high\u2010intensity focused ultrasound (HIFU) on subcutaneous fat thickness in axillary accessory breast tissue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This prospective\u00a0study enrolled 30 women with BMI \u226527\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      and accessory breast fat. All participants underwent a single HIFU session using multiple focal depths of 4.5, 6.0, and 9.0\u2009mm at operating frequencies of 4 and 2\u2009MHz, with energy settings of 1.5\u20132.0\u2009J per shot. Fat thickness was measured by ultrasound at baseline and 8\u2009weeks. Secondary outcomes included investigator\u2010rated Global Aesthetic Improvement Scale (GAIS) and patient satisfaction scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among the 28 participants who completed the 8\u2010week follow\u2010up, mean subcutaneous fat thickness decreased from 19.2\u2009\u00b1\u20093.4\u2009mm at baseline to 15.8\u2009\u00b1\u20093.1\u2009mm at 8\u2009weeks. The mean paired reduction was 3.4 \u00b1 1.6 mm (17.7%), which was statistically significant (95% CI, 2.8\u20134.0 mm; p = 1.1 \u00d7 10\u207b\u00b9\u00b9). All participants showed GAIS improvement with high satisfaction. No serious adverse events were observed; mild and transient effects included transient thermal discomfort and localized erythema resolving within several hours to 2\u2009days, and no cases of skin burn were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Non\u2010invasive HIFU produced a measurable reduction of accessory breast fat with favorable esthetic outcomes and an acceptable safety profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70238","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:53:52Z","timestamp":1778298832000},"page":"1877-1888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Non\u2010invasive Reduction of Accessory Breast Fat Using Multilayer High\u2010Intensity Focused Ultrasound: A Quantitative Ultrasound\u2010Based Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-1364","authenticated-orcid":false,"given":"Kyu\u2010Ho","family":"Yi","sequence":"first","affiliation":[{"name":"You and I Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerin","family":"Park","sequence":"additional","affiliation":[{"name":"Medical Research  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena","family":"Sydorchuk","sequence":"additional","affiliation":[{"name":"Medical Research  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugues","family":"Cartier","sequence":"additional","affiliation":[{"name":"Centre M\u00e9dical Saint Jean  Arras France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Garson","sequence":"additional","affiliation":[{"name":"Cabinet M\u00e9dical  Senlis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Ascher","sequence":"additional","affiliation":[{"name":"SIBUS\u2010In  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.33545\/surgery.2025.v9.i4.B.1262"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2022.01.051"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00266-016-0729-3"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2298\/VSP240429041G"},{"key":"e_1_2_9_6_1","first-page":"127","article-title":"Surgical management of accessory breast tissue: liposuction and mastectomy in axillary localization \u2013 a case series","volume":"67","author":"Ar\u2010Reyouchi D","year":"2025","journal-title":"Acta Chir 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