{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:28:22Z","timestamp":1787171302967,"version":"build-2736575974"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T00:00:00Z","timestamp":1776038400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To prospectively validate the association between fetal heart rate (FHR) at the 12\u2010week scan and the risk of preterm birth (PTB), including spontaneous preterm birth (sPTB).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study included 1276 singleton pregnancies undergoing routine first\u2010trimester screening at 11\u201313\u2009+\u20096\u2009weeks' gestation and followed until delivery. Associations between FHR and PTB outcomes were assessed using univariable and multivariable logistic regression analyses and receiver operating characteristic (ROC) curves, incorporating clinical, sonographic, and biochemical first\u2010trimester parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Compared with term births, pregnancies resulting in PTB (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200934) and sPTB (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200923) showed significantly higher FHR at the 12\u2010week scan (163.6 versus 160.1\u2009bpm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.007; and 164.1 versus 160.1\u2009bpm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.014, respectively). In univariable analyses, FHR was the only parameter consistently associated with PTB, PTB &lt;34\u2009weeks, sPTB, and sPTB &lt;34\u2009weeks (odds ratios per bpm increase ranging from 1.08 to 1.12). Free \u03b2\u2010human chorionic gonadotropin (free\u2010\u03b2hCG) was associated with PTB &lt;34\u2009weeks and showed borderline significance for other PTB outcomes. In multivariable models, FHR showed the highest predictive performance for sPTB &lt;34\u2009weeks (AUC 0.73; detection rate 25% at a 10% false\u2010positive rate), which improved when combined with free\u2010\u03b2hCG (AUC 0.81; detection rate 43% at a 10% false\u2010positive rate).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Elevated FHR at the 12\u2010week scan is associated with sPTB, particularly before 34\u2009weeks' gestation. FHR, especially when combined with free\u2010\u03b2hCG, may contribute to early first\u2010trimester screening strategies for sPTB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70252","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T09:41:40Z","timestamp":1776073300000},"page":"1949-1963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Fetal Heart Rate at 12 Weeks' Gestation and the Risk of Preterm Birth"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8783-6710","authenticated-orcid":false,"given":"Jos\u00e9","family":"Morales\u2010Rosell\u00f3","sequence":"first","affiliation":[{"name":"Servicio de Obstetricia y Ginecolog\u00eda Hospital Universitario y Polit\u00e9cnico La  Valencia Spain"},{"name":"Departamento de Pediatr\u00eda Obstetricia y Ginecolog\u00eda, Universidad de Valencia  Valencia 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