{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:28:22Z","timestamp":1787171302094,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302085"],"award-info":[{"award-number":["82302085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017958","name":"Health Commission of Hubei Province","doi-asserted-by":"publisher","award":["WJ2023Z007"],"award-info":[{"award-number":["WJ2023Z007"]}],"id":[{"id":"10.13039\/100017958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Natural Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2025AFD691;2025AFD847;2025BCB026"],"award-info":[{"award-number":["2025AFD691;2025AFD847;2025BCB026"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This retrospective study aims to develop and validate a multimodal nomogram for the prenatal risk assessment of hypoplastic left heart syndrome (HLHS) and to explore significant risk factors for HLHS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study enrolled 161 normal pregnancies and 52 pregnancies diagnosed with HLHS at the Ultrasound Diagnosis Department of Maternal and Child Health Hospital of Hubei Province in China from September 2019 to September 2023. Experienced sonographers selected standard 4\u2010chamber cardiac views and delineated the boundaries of the left and right atria and ventricles. A ResNet\u2010like variational autoencoder (RVAE) was used to extract features from 4\u2010chamber views in a self\u2010supervised learning strategy. These features were then converted into an image score. The proposed multimodal nomogram was developed using univariate and multivariate logistic regression analysis, incorporating the image score, demographics, and morphological characteristics of the fetus' heart. To evaluate the nomogram's performance, we constructed a clinical regression model, 4 machine learning (ML) models, and an expert model comprising 3 sonographers with varying years of clinical experience.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The study identified several significant risk factors for assessing the risk of HLHS, including the diameter of the left ventricle, the area ratio between the left and right atrium, the area ratio between the left and right ventricle, and the image score calculated from the 4\u2010chamber view. A multimodal nomogram was constructed based on these factors, achieving an accuracy of 0.935 and an AUC of 0.991. The performance of the nomogram was better than that of the traditional logistic regression and ML models, and comparable to that of the expert model. Additionally, the multimodal nomogram outperforms sonographers with 3\u2010 and 6\u2010year experience, and performs only slightly worse than the sonographer with 10\u2010year experience. When combined with the heat\u2010map generated from RVAE, the nomogram can serve as an easy\u2010to\u2010use tool to help clinicians better understand the process of computer\u2010aided diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The proposed multimodal nomogram demonstrates its superiority, effectiveness, and interpretability in prenatal risk assessment of HLHS. Additionally, 2 risk factors, ie, the area ratio between the left and right atrium and the area ratio between the ventricle, deserve further investigation during clinical diagnosis of HLHS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70254","type":"journal-article","created":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:26:08Z","timestamp":1778300768000},"page":"1983-1999","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multimodal Nomogram for the Prenatal Risk Assessment of Hypoplastic Left Heart Syndrome Using Self\u2010Supervised Learning"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-0864","authenticated-orcid":false,"given":"Xinglong","family":"Wu","sequence":"first","affiliation":[{"name":"School of Computer Science and Engineering, Hubei Key Laboratory of Intelligent Robot Wuhan Institute of Technology  Wuhan People's Republic of 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