{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:28:26Z","timestamp":1787171306626,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T00:00:00Z","timestamp":1776211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82272002"],"award-info":[{"award-number":["82272002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901747"],"award-info":[{"award-number":["81901747"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate whether the addition of whole\u2010gland contrast\u2010enhanced transrectal ultrasound (CETRUS) and fixed\u2010plane flash\u2010replenishment imaging (FRI) to conventional transrectal ultrasound (TRUS) improves the diagnostic efficacy of prostate cancer (PCa) in patients with prostate\u2010specific antigen (PSA) levels of 4.00\u201320.00\u2009ng\/mL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 163 patients scheduled for TRUS\u2010guided biopsy due to elevated PSA (4.00\u201320.00\u2009ng\/mL) were enrolled. Each patient underwent conventional TRUS, whole\u2010gland CETRUS, and FRI before biopsy. Detection rates and diagnostic efficacy for PCa were compared among 3 imaging strategies: conventional TRUS alone, the combination of conventional TRUS with whole\u2010gland CETRUS, and the triple combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      PCa was diagnosed in 62 of 163 (38.04%), including 29 (46.77%) clinically significant cases. The detection rates were 43.56% for conventional TRUS, 57.06% for conventional TRUS combined with whole\u2010gland CETRUS, and 61.35% for the triple combination. Only 5 clinically insignificant cases were missed by the combined approach. The triple combination demonstrated the highest area under the ROC curve (AUC\u2009=\u20090.747), significantly outperforming conventional TRUS (AUC\u2009=\u20090.669,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.018) and TRUS with whole\u2010gland CETRUS (AUC\u2009=\u20090.703,\n                      <jats:italic>p\u2009=<\/jats:italic>\n                      \u2009.026). The combined method also identified significantly more positive biopsy cores\n                      <jats:italic>(p<\/jats:italic>\n                      \u2010\n                      <jats:sub>\n                        <jats:italic>Bonf<\/jats:italic>\n                      <\/jats:sub>\n                      \u2009&lt;\u2009.001) by integrating the complementary diagnostic strengths of whole\u2010gland CETRUS (high positive predictive value (PPV) for rapid\/hyperenhancement and diffuse abnormalities) and FRI (high PPV for asymmetric\/focal enhancement).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The triple\u2010modality combination significantly improves PCa detection rate and diagnostic efficacy in patients with PSA levels of 4.00\u201320.00\u2009ng\/mL, offering a valuable alternative when magnetic resonance imaging is contraindicated or unavailable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70264","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T13:01:38Z","timestamp":1776258098000},"page":"2029-2038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sweep and Scrutinize: Improving Prostate Cancer Diagnostic Efficacy by Combining Whole\u2010Gland Contrast\u2010Enhanced Transrectal Ultrasound With Fixed\u2010Plane Flash\u2010Replenishment Imaging"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8809-8611","authenticated-orcid":false,"given":"Xiaoyuan","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Ultrasound Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai 200127 China"},{"name":"Department of Ultrasound Baoshan Hospital Affiliated to Shanghai University of Traditional Chinese Medicine  Shanghai 201999 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