{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:20:11Z","timestamp":1791922811172,"version":"4.3.4"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2025B03J0102"],"award-info":[{"award-number":["2025B03J0102"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004104"],"award-info":[{"award-number":["2018YFC1004104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To assess the predictive significance of the uterine artery pulsatility index (UTPI) for placental insufficiency (PI) during different stages of pregnancy within the same population, identify the optimal detection window, and elucidate its dynamic variation patterns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Standardized UTPI measurements were obtained at 6 gestational stages (11\u201313\n                      <jats:sup>+6<\/jats:sup>\n                      w to 32\u201336\n                      <jats:sup>+6<\/jats:sup>\n                      w). PI, including preeclampsia (PE) and fetal growth restriction (FGR), was the primary outcome. Longitudinal UTPI trends were analyzed using generalized linear mixed models, and gestational stage\u2010specific predictive performance was assessed using receiver operating characteristic (ROC) analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 129 high\u2010risk singleton pregnancies were included (114 normal, 15 with PI). UTPI decreased with advancing gestation in both groups (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u2009\u22120.195,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001) but remained consistently higher in the PI group. The predictive performance varied by gestational stage, peaking at 24\u201327\n                      <jats:sup>+6<\/jats:sup>\n                      w (AUC 0.79, 95% confidence interval (CI) 0.64\u20130.92; sensitivity 80.0%, 95% CI 50.0\u2013100.0; specificity 74.6%, 95% CI 69.0\u201396.0). At 28\u201331\n                      <jats:sup>+6<\/jats:sup>\n                      weeks, the UTPI showed comparable discriminative ability (AUC 0.78, 95% CI 0.62\u20130.92), with moderate sensitivity (66.7%, 95% CI 47.0\u2013100.0) and high specificity (83.3%, 95% CI 45.0\u201397.0).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The UTPI has a gestational stage\u2010dependent predictive value for PI, with optimal discrimination at 24\u201327\n                      <jats:sup>+6<\/jats:sup>\n                      weeks and a subsequent risk\u2010confirmation phase at 28\u201331\n                      <jats:sup>+6<\/jats:sup>\n                      weeks. Both groups exhibited similar UTPI decline patterns, indicating the presence of hemodynamic compensation in PI patients. These findings support the use of a phased UTPI monitoring strategy in high\u2010risk pregnancies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70271","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:01:36Z","timestamp":1777352496000},"page":"2141-2152","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictive Value of Uterine Artery Pulsatility Index in Placental Insufficiency Across Gestational Stages in a Single Population"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5889-5636","authenticated-orcid":false,"given":"Xiongpeng","family":"He","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5266-9692","authenticated-orcid":false,"given":"Xiaojuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Department of Fetal Medicine and Prenatal Diagnosis; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Higher Education Joint Laboratory of Maternal\u2010Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suyi","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Department of Fetal Medicine and Prenatal Diagnosis; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Higher Education Joint Laboratory of Maternal\u2010Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingya","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Department of Fetal Medicine and Prenatal Diagnosis; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Higher Education Joint Laboratory of Maternal\u2010Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center For Obstetrics and Gynecology, Guangdong \u2010 Hong Kong \u2010 Macao Greater Bay Area Higher Education Joint Laboratory of Maternal \u2010 Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Department of Fetal Medicine and Prenatal Diagnosis; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Higher Education Joint Laboratory of Maternal\u2010Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Department of Fetal Medicine and Prenatal Diagnosis; Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong\u2010Hong Kong\u2010Macao Greater Bay Area Higher Education Joint Laboratory of Maternal\u2010Fetal Medicine The Third Affiliated Hospital, Guangzhou Medical University  Guangzhou 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