{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:02:11Z","timestamp":1789534931538,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"\n Objective<\/jats:title>\n \n This study aimed to evaluate the efficacy and safety of ultrasound\u2010guided radioactive iodine\u2010125 (\n 125<\/jats:sup>\n I) seed implantation as a local treatment for metastatic cervical lymph nodes.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We conducted a retrospective analysis of 29 patients (with a total of 53 metastatic lymph nodes) who underwent the procedure between January 2021 and December 2023. Under ultrasound guidance,\n 125<\/jats:sup>\n I seeds were percutaneously implanted according to a pre\u2010planned dose distribution. Treatment response was assessed using contrast\u2010enhanced CT at 3, 6, and 12\u2009months post\u2010implantation, based on RECIST 1.1 criteria. Overall survival was estimated using the Kaplan\u2013Meier method.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n All procedures were technically successful. Over a mean follow\u2010up of 15\u2009\u00b1\u200910.5\u2009months (range: 7\u201326). Local tumor control rates were 90.5%, 91.1%, and 75.9% at 3, 6, and 12\u2009months, respectively. The 1\u2010year and 2\u2010year overall survival rates for patients were 55.2% and 37.9%; however, these results should be interpreted cautiously due to the small sample size and heterogeneity of primary tumors. The complication profile was favorable, with only one case (3.4%) of skin injury; other adverse events were minor and manageable.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Ultrasound\u2010guided\n 125<\/jats:sup>\n I seed implantation is a feasible, safe, and effective local treatment option for metastatic cervical lymph nodes, offering high rates of local tumor control with minimal morbidity. It represents a valuable salvage or alternative therapy for this clinically challenging condition.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/jum.70303","type":"journal-article","created":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T15:44:37Z","timestamp":1779723877000},"page":"2229-2235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound\u2010Guided Iodine\u2010125 Seed Implantation for Cervical Metastatic Lymph Nodes: An Analysis of Efficacy and Safety"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3728-8493","authenticated-orcid":false,"given":"Huarong","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ultrasound Aerospace Center Hospital Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Aerospace Center Hospital Beijing 100049 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0615-8816","authenticated-orcid":false,"given":"Jianming","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Interventional Ultrasound, Department of Oncology Chinese PLA General Hospital Beijing 100853 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