{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T05:02:10Z","timestamp":1789534930487,"version":"build-2803163510"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Ultrasound Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Lung ultrasound (LUS) quantifying B\u2010lines is valuable to assess fluid status during hemodialysis. However, B\u2010lines may indicate not only cardiogenic pulmonary edema (CPE) but also non\u2010cardiogenic pulmonary diseases, such as pneumonia or interstitial lung disease, posing challenges to guiding fluid therapy decisions. We developed a combined cardiac\u2010LUS diagnostic model to differentiate these etiologies, aiming to prevent misdiagnosis and optimize treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective observational study enrolled chronic kidney disease (CKD) stage 3\u20135 patients divided into training and validation cohorts. Participants were classified into CPE group or non\u2010cardiogenic dyspnea (NCD) group. Multivariable logistic regression identified discriminative echocardiographic and LUS parameters to build a diagnostic model. Predictive performance was assessed using receiver operator characteristic (ROC), calibration and decision curve analysis. A simplified \u03b2\u2010weighted scoring system was developed and evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This retrospective study analyzed 215 training and 56 validation participants. Multivariable regression identified E\/e\u2032 (OR 1.180, 95% CI 1.067\u20131.304,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.001), inferior vena cava diameter (OR 1.240, 95% CI 1.023\u20131.503,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.029), bilateral symmetric B\u2010pattern (OR 9.720, 95% CI 2.707\u201334.899,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), bilateral continuous B\u2010pattern (OR 13.777, 95% CI 3.666\u201351.770,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), \u22651 irregular pleural line region (OR 0.078, 95% CI 0.018\u20130.326,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), \u22651 consolidation region (OR 0.039, 95% CI 0.008\u20130.196,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u2009.001), \u22651 pleural effusion region (OR 4.732, 95% CI 1.148\u201319.510,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009.032) as independent CPE predictors. The nomogram showed good discrimination, with area under the curve (AUC) of 0.9703 (training) and 0.8910 (validation). The \u03b2\u2010weighted scoring system (cut\u2010off as 42.99 scores) showed an AUC of 0.968 (training) and 0.888 (validation).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The nomogram model demonstrated that the ultrasound parameters and \u03b2\u2010weighted scoring system possess reliable clinical application value and high predictive accuracy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jum.70317","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:06:49Z","timestamp":1779887209000},"page":"2311-2327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Predictive Model Based on Cardio and Lung Ultrasound Features for Differential Diagnosis of Cardiogenic and Non\u2010cardiogenic Dyspnea in Patients With Chronic Kidney Disease: A Single\u2010Center Observational Study"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3915-8828","authenticated-orcid":false,"given":"Haotian","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Ultrasound Medicine Hebei Medical University  Shijiazhuang China"},{"name":"Department of Ultrasound Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ze","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5786-0189","authenticated-orcid":false,"given":"Ling","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaru","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Hebei Medical University  Shijiazhuang China"},{"name":"Department of Ultrasound Shijiazhuang People's Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zekai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nephrology Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heling","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8359-8689","authenticated-orcid":false,"given":"Yuquan","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine Hebei Medical University  Shijiazhuang China"},{"name":"Department of Ultrasound Hebei General Hospital  Shijiazhuang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.01.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1488"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.07.025"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.01.450"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2019.09.004"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.suppl_1.29"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae167"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.12.008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.001918"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa182"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012100990"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.02.018"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1811"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-024-05102-y"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfaa104"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3523"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-08620-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06186-0"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-021-06515-x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcu.24072"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics14060589"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2023"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2011.32"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2025.04.008"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60091521"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000542012"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina60071140"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-0341"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2024.1357006"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13613-017-0348-4"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc11339"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2800"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40477-024-00941-5"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000004855"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.05190418"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2020.05.005"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.0703"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/arm92030024"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-1313"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/RUQ.0000000000000598"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-05996-6"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.0186-2023"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-96380-x"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMvcm2108203"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-012-2513-4"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16088"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-025-07932-y"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13089-025-00401-z"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000005620"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-03299-w"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2024.108316"}],"container-title":["Journal of Ultrasound in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70317","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jum.70317","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jum.70317","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T04:05:17Z","timestamp":1789531517000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jum.70317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,27]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/jum.70317"],"URL":"https:\/\/doi.org\/10.1002\/jum.70317","archive":["Portico"],"relation":{},"ISSN":["0278-4297","1550-9613"],"issn-type":[{"value":"0278-4297","type":"print"},{"value":"1550-9613","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,27]]},"assertion":[{"value":"2025-08-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}